{"product_id":"recombinant-bovine-phosphoinositide-3-kinase-alpha-p110a-p85a-bhp11001617","title":"Recombinant bovine  Phosphoinositide 3-kinase alpha p110a\/p85a","description":"\u003cp\u003e\u003cstrong\u003eRecombinant bovine  Phosphoinositide 3-kinase alpha p110a\/p85a\u003c\/strong\u003e is supplied as a recombinant protein for in vitro research use.\u003c\/p\u003e\n\u003ch3\u003eBackground\u003c\/h3\u003e\n\u003cp\u003ePI3Ka plays a specific role in apoptosis in human colon cancer cells. Injection of neutralizing antibodies specific to PI3Ka into adenocarcinoma cells induced apoptosis, a response that was reverted by treating cells with caspase inhibitor. It was also shown that PI3Ka mediated phosphorylation of the p85a adapter reduces the lipid kinase activity of the heterodimer and this gives hints for PI3K-dependent signaling events not requiring production of 3’-phosphorylated phosphoinositides. PI3Ka is a key regulator of the initiation of keratinocyte differentiation. A decrease in PI3Ka activity results in a loss of keratinocyte adhesion to the extracellular membrane and the initiation of early phase differentiation.\u003c\/p\u003e\n\u003ch3\u003eProduct format\u003c\/h3\u003e\n\u003cp\u003eProvided as a recombinant protein suitable for in vitro workflows such as binding studies, screening, and assay development. Refer to the specifications table for expression format and molecular properties.\u003c\/p\u003e\n\u003ch3\u003eActivity \u0026amp; assay information\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eUnit Definition:\u003c\/strong\u003e 1 unit is defined as 1 picomole phosphate transferred to PIP2 per minute.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSpecific Activity:\u003c\/strong\u003e 1,000 U\/mg.\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"ProSpec-Tany TechnoGene Ltd","offers":[{"title":"1 ug","offer_id":53038067908973,"sku":"pka-327-1UG","price":130.0,"currency_code":"USD","in_stock":true},{"title":"2.5 ug","offer_id":53038319010157,"sku":"pka-327-25UG","price":250.0,"currency_code":"USD","in_stock":true},{"title":"5 ug","offer_id":53038319042925,"sku":"pka-327-5UG","price":450.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/Prospecbio-pi3ka-bovine-PKA-327.png?v=1782158165","url":"https:\/\/www.ebiohippo.com\/products\/recombinant-bovine-phosphoinositide-3-kinase-alpha-p110a-p85a-bhp11001617","provider":"BioHippo","version":"1.0","type":"link"}