{"product_id":"recombinant-cd63-antibody-lamp-3-bha17116077","title":"Recombinant CD63 Antibody \/ LAMP-3","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eThis mAb recognizes protein of 26kDa-60kDa, which is identified as CD63\/LAMP-3. The tetraspanins are integral membrane proteins expressed on cell surface and granular membranes of hematopoietic cells and are components of multi-molecular complexes with specific integrins. The tetraspanin CD63\/LAMP-3 is a lysosomal membrane glycoprotein that translocates to the plasma membrane after platelet activation. It is expressed on activated platelets, monocytes and macrophages, and is weakly expressed on granulocytes, T cell and B cells. It is located on the basophilic granule membranes and on the plasma membranes of lymphocytes and granulocytes. CD63 is a member of the TM4 superfamily of leukocyte glycoproteins that includes CD9, CD37 and CD53, which contain four transmembrane regions. CD63\/LAMP-3 may play a role in phagocytic and intracellular lysosome-phagosome fusion events. Deficiency is associated with Hermansky-Pudlak syndrome and is strongly expressed during the early stages of melanoma progression.\u003c\/p\u003e\u003cp\u003eThis anti-LAMP-3 antibody is supplied as Purified (Rabbit, Recombinant Rabbit Monoclonal, clone LAMP3\/2990R, Rabbit IgG, kappa, Unconjugated) and is designed to support common target-detection workflows after the on-page specifications.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e LAMP-3\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Purified\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eLocalization:\u003c\/strong\u003e Cytoplasmic\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSpecies reactivity:\u003c\/strong\u003e Human\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (listed):\u003c\/strong\u003e FACS, IHC-P\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eConjugate:\u003c\/strong\u003e Unconjugated\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eClone and antibody class:\u003c\/strong\u003e Recombinant Rabbit Monoclonal, clone LAMP3\/2990R, Rabbit IgG, kappa\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eBecause antibody performance can depend on epitope context, sample preparation, and biological state, interpret signals using appropriate controls and orthogonal evidence when possible.\u003c\/p\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cp\u003eLAMP-3 is referenced in public gene\/protein resources (e.g., UniProt and NCBI Gene), which provide curated names\/synonyms, protein features, and pathway context. When designing assays, consider potential isoforms, post-translational modifications, and cell-type specific expression that may influence observed signal.\u003c\/p\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eProfiling LAMP-3 expression across model systems, perturbations, and time points to support mechanistic hypotheses.\u003c\/li\u003e\n\u003cli\u003eCombining antibody-based detection with multi-omics or imaging readouts to link LAMP-3 signal with phenotype.\u003c\/li\u003e\n\u003cli\u003eUsing well-matched controls (isotype controls, genetic perturbations, or independent reagents) to strengthen interpretation of target-associated signal.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eFACS\u003c\/li\u003e\n\u003cli\u003eIHC-P\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eUse the listed applications as a starting point and tailor experimental design to your sample type and readout requirements.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eSpecificity considerations:\u003c\/strong\u003e closely related family members, isoforms, or PTMs can affect apparent specificity; confirm with independent approaches when critical.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eControls:\u003c\/strong\u003e include negative controls and, when feasible, genetic or pharmacologic perturbations to support target attribution in your system.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSpecies and sample context:\u003c\/strong\u003e differences in sequence, expression, fixation, or extraction conditions can change signal behavior across models.\u003c\/li\u003e\n\u003c\/ul\u003e\u003c!-- Sources (internal): - UniProt Knowledgebase — UniProt — https:\/\/www.uniprot.org\/ - NCBI Gene — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/ - Ensembl Genome Browser — EMBL-EBI — https:\/\/www.ensembl.org\/ - Human Protein Atlas — SciLifeLab\/KTH — https:\/\/www.proteinatlas.org\/ - Gene Ontology — GO Consortium — https:\/\/geneontology.org\/ - Reactome Pathway Database — Reactome — https:\/\/reactome.org\/ - PubMed — NCBI — https:\/\/pubmed.ncbi.nlm.nih.gov\/ --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"0.2 mg\/ml in 1X PBS with 0.1 mg\/ml BSA (US sourced) and 0.05% sodium azide \/ 100 ug","offer_id":53045170504045,"sku":"V7373-100UG","price":559.0,"currency_code":"USD","in_stock":true},{"title":"0.2 mg\/ml in 1X PBS with 0.1 mg\/ml BSA (US sourced) and 0.05% sodium azide \/ 20 ug","offer_id":53045328773485,"sku":"V7373-20UG","price":259.0,"currency_code":"USD","in_stock":true},{"title":"Prediluted in 1X PBS, 0.1 mg\/ml BSA (US sourced), 0.05% sodium azide; *For IHC use only* \/ 7 ml","offer_id":53045328806253,"sku":"V7373IHC-7ML","price":559.0,"currency_code":"USD","in_stock":true},{"title":"1 mg\/ml in 1X PBS; BSA free, sodium azide free \/ 100 ug","offer_id":53045328839021,"sku":"V7373SAF-100UG","price":559.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_6eb784ba-68dd-4520-9608-e88e9c7b8e0e.jpg?v=1771953098","url":"https:\/\/www.ebiohippo.com\/products\/recombinant-cd63-antibody-lamp-3-bha17116077","provider":"BioHippo","version":"1.0","type":"link"}