{"product_id":"recombinant-deoxyribonuclease-i-dnase-i-rnase-free-gmp-grade-2-u-mu-l-bhz20800008","title":"Recombinant Deoxyribonuclease I (DNase I, RNase-free) GMP-grade (2 U\/μL)","description":"\u003cdiv class=\"top_tabc proDetail\"\u003e\n\u003cdiv\u003e\n\u003cdiv\u003e\n\u003cp\u003e\u003cspan\u003eDNase I is an endonuclease that can digest single-stranded and double-stranded DNA to produce single deoxynucleotides or single-stranded or double-stranded oligodeoxynucleotides. It can hydrolyze the phosphodiester bond to produce monodeoxynucleotides and oligodeoxynucleotides containing 5'-phosphate groups and 3'-OH groups. The average digestion product is the smallest polytetranucleotide. DNase I can catalyze many forms of DNA, such as single-stranded DNA, double-stranded DNA, and even chromatin (its cutting rate is affected by histones). The optimum pH range is 7-8. The activity of DNase I depends on Ca\u003csup\u003e2+\u003c\/sup\u003e and can be activated by divalent metal ions, such as Co\u003csup\u003e2+\u003c\/sup\u003e, Mn\u003csup\u003e2+\u003c\/sup\u003e, Zn\u003csup\u003e2+\u003c\/sup\u003e, etc. 5 mM Ca\u003csup\u003e2+\u003c\/sup\u003e can protect the enzyme from being hydrolyzed. In the presence of Mg\u003csup\u003e2+\u003c\/sup\u003e, the enzyme can recognize and cut any site on any strand of DNA randomly; and in the presence of Mn\u003csup\u003e2+\u003c\/sup\u003e, it can recognize two strands of DNA at the same time and cut at almost the same site to form blunt ends, Or sticky ends with 1-2 nucleotides protruding. DNase I is widely used in the preparation of DNA-free RNA; remove the template DNA after in vitro transcription; prepare DNA-free RNA before RT-PCR and RT-qPCR reactions; combine with DNA polymerase I to perform DNA labeling through nick translocation; DNA fragmentation library construction.\u003cbr\u003eThis product is produced in accordance with GMP process requirements, and the product is provided in liquid form.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e\u003cstrong\u003eFeature\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan\u003eDNA specific Endonuclease\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eDegrades double-stranded and single-stranded DNA\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eProducts are short oligos with 5'-phosphate and 3'-OH\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cspan\u003e\u003cstrong\u003eApplication\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan\u003eRemoval of contaminating genomic DNA from RNA samples\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eDegradation of DNA templates in transcription reactions\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3 class=\"H3_backgro\"\u003e\u003cstrong\u003e\u003cspan\u003eSpecification\u003c\/span\u003e\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cdiv class=\"tableResponsive\"\u003e\n\u003ctable cellspacing=\"0\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cspan\u003eSource\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003cspan\u003eRecombinant E. coli with DNase I gene\u003c\/span\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cspan\u003eOptimum temperature\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003cspan\u003e37℃\u003c\/span\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cspan\u003eStorage Buffer\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003cspan\u003e10 mM Tris-HCl pH 7.6，2 mM CaCl\u003csub\u003e2\u003c\/sub\u003e, 50% (v\/v) Glycerol \u003c\/span\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cspan\u003eUnit Definition\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003cspan\u003eThe amount of enzyme required to completely degrade 1 μg of plasmid DNA within 10 min at 37°C. (The reaction buffer is: 10 mM Tris-HCl pH 7.6, 2.5 mM MgCl\u003csub\u003e2\u003c\/sub\u003e, 0.5 mM CaCl\u003csub\u003e2\u003c\/sub\u003e, 1 μg plasmid DNA)\u003c\/span\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003c\/div\u003e\n\u003ch3 class=\"H3_backgro\"\u003e\u003cstrong\u003e\u003cspan\u003eComponents\u003c\/span\u003e\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cdiv class=\"tableResponsive\"\u003e\n\u003ctable cellspacing=\"0\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cspan\u003eComponents No.\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003cspan\u003eName\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd\u003e\n\u003cspan\u003e10611ES76\u003c\/span\u003e\u003cspan\u003e \u003c\/span\u003e\u003cspan\u003e(500 U)\u003c\/span\u003e\n\u003c\/td\u003e\n\u003ctd\u003e\n\u003cspan\u003e10611ES84\u003c\/span\u003e\u003cspan\u003e \u003c\/span\u003e\u003cspan\u003e(2,000 U)\u003c\/span\u003e\n\u003c\/td\u003e\n\u003ctd\u003e\n\u003cspan\u003e10611ES92\u003c\/span\u003e\u003cspan\u003e \u003c\/span\u003e\u003cspan\u003e(10,000 U)\u003c\/span\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cspan\u003e10611\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003cspan\u003eDeoxyribonuclease I (DNase I) GMP-grade (2 U\/μL)\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003cspan\u003e250 μL\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003cspan\u003e1 mL\u003c\/span\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003cspan\u003e5 mL\u003c\/span\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003c\/div\u003e\n\u003ch3 class=\"H3_backgro\"\u003e\u003cstrong\u003e\u003cspan\u003eShipping and Storage\u003c\/span\u003e\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cp\u003e\u003cspan\u003eDeoxyribonuclease I (DNase I) GMP-grade products are shipped with dry ice and can be stored at -15℃ ~ -25℃ for one year.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch3 class=\"H3_backgro\"\u003e\u003cstrong\u003e\u003cspan\u003eFigures\u003c\/span\u003e\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cp\u003e\u003cspan\u003e\u003cimg src=\"https:\/\/seas.ysbuy.com\/file\/309671\/68ab-167030548627849912.png\"\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003eFigure 1. DNase I from YEASEN could effectively remove DNA template during transcription，compared with competitor brands.\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"top_tabc\"\u003e\n\u003cspan class=\"boxTap\" id=\"tabCBox1\"\u003eDocuments:\u003c\/span\u003e\n\u003cdiv\u003e\n\u003cdiv class=\"cwrap\"\u003e\n\u003cdiv\u003e\n\u003cdiv class=\"list\"\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003cdiv class=\"list\"\u003e\n\u003cdiv\u003e\n\u003cdiv class=\"title\"\u003eSafety Data Sheet\u003c\/div\u003e\n\u003cdiv\u003e\u003ca class=\"down\" download=\"\" href=\"https:\/\/seas.yeasenbiotech.com\/prod\/doc\/mainDoc\/MSDS-10611-Deoxyribonuclease%20I%20(DNase%20I)%20GMP-grade%20(2%20U_%CE%BCL)-HB220701.pdf\" target=\"_blank\" title=\"download\"\u003e\u003cimg alt=\"\" src=\"data:image\/png;base64,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\"\u003e\n\u003cp\u003eMSDS-10611-Deoxyribonuclease I (DNase I) GMP-grade (2 U_μL)-HB220701.pdf\u003c\/p\u003e\n\u003c\/a\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"list\"\u003e\n\u003cdiv\u003e\n\u003cdiv class=\"title\"\u003eManuals\u003c\/div\u003e\n\u003cdiv\u003e\u003ca class=\"down\" download=\"\" href=\"https:\/\/seas.yeasenbiotech.com\/prod\/doc\/mainDoc\/10611_Manual_HB221110_EN.pdf\" target=\"_blank\" title=\"download\"\u003e\u003cimg alt=\"\" src=\"data:image\/png;base64,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\"\u003e\n\u003cp\u003e10611_Manual_HB221110_EN.pdf\u003c\/p\u003e\n\u003c\/a\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"list\"\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"top_tabc\"\u003e\n\u003cspan class=\"boxTap\" id=\"tabCBox3\"\u003eCitations \u0026amp; References:\u003c\/span\u003e\n\u003cdiv\u003e\n\u003cdiv\u003e\n\u003cp\u003e\u003cspan\u003e[1] Lu Z, Liu H, Song N, et al. METTL14 aggravates podocyte injury and glomerulopathy progression through N\u003csup\u003e6\u003c\/sup\u003e-methyladenosine-dependent downregulating of Sirt1. Cell Death Dis. 2021;12(10):881. Published 2021 Sep 27. doi:10.1038\/s41419-021-04156-y(IF:8.469)\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e[2] Yu Y, Wang Y, Zhang W, et al. Biomimetic periosteum-bone substitute composed of preosteoblast-derived matrix and hydrogel for large segmental bone defect repair. Acta Biomater. 2020;113:317-327. doi:10.1016\/j.actbio.2020.06.030(IF:7.242)\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"top_tabc\"\u003e\u003cspan class=\"boxTap\" id=\"tabCBox4\"\u003eCOA\u003c\/span\u003e\u003c\/div\u003e\n\u003cdiv class=\"top_tabc\"\u003e\n\u003cspan class=\"boxTap\"\u003e\u003c\/span\u003e\u003cbr\u003e\n\u003c\/div\u003e\u003cp\u003e\u003cstrong\u003eGlycerol Content:\u003c\/strong\u003e Contains Glycerol\u003c\/p\u003e","brand":"Yeasen Biotechnology","offers":[{"title":"500 U","offer_id":53294151041389,"sku":"10611ES76","price":35.0,"currency_code":"USD","in_stock":true},{"title":"2000 U","offer_id":53294159036781,"sku":"10611ES84","price":105.0,"currency_code":"USD","in_stock":true},{"title":"10000 U","offer_id":53294159069549,"sku":"10611ES92","price":515.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/6420f6029932881a5e824439.webp?v=1778482769","url":"https:\/\/www.ebiohippo.com\/products\/recombinant-deoxyribonuclease-i-dnase-i-rnase-free-gmp-grade-2-u-mu-l-bhz20800008","provider":"BioHippo","version":"1.0","type":"link"}