{"product_id":"recombinant-helicobacter-pylori-cytotoxin-associated-gene-a-bhp11005290","title":"Recombinant Helicobacter Pylori Cytotoxin-Associated Gene A","description":"\u003cp\u003e\u003cstrong\u003eRecombinant Helicobacter Pylori Cytotoxin-Associated Gene A\u003c\/strong\u003e is supplied as a recombinant protein for in vitro research use.\u003c\/p\u003e\n\u003ch3\u003eBackground\u003c\/h3\u003e\n\u003cp\u003eHelicobacter pylori is a Gram negative bacteria which colonizes in the human stomach and stimulates gastric mucosal inflammations leading to acute gastritis-associated diseases among them are atrophic gastritis, peptic ulcer and gastric cancer. H. pylori is found in half of the world’s population and is defined as a group I carcinogens. . An important virulence factor of H. pylori is Cytotoxin-associated gene A (CagA) which is located at the end of an approximately 40-kb cluster of genes called cag pathoge¬nicity island (PAI). Cag PAI encodes a type-IV secretion system and transfers CagA protein into the intracellular region of gastric epithelial cell. This relocation induces cellular hyper proliferation, apoptosis and leading to failure of gastric epithelial cell in maintaining its normal cytoskeletal structure. Furthermore it increases the secretion of cytokines such as tumor necrosis factor (TNF) and interleukin (IL) 1, 6 and 8 by the epithelial cells. The IL-8 leads to extreme inflammatory responses and also stimulates the production of oxygen free radicals that could cause DNA damage to adjacent cells and lead to genetic modifications of gastric epithelial cells which are carcinogenic.\u003c\/p\u003e\n\u003ch3\u003eProduct format\u003c\/h3\u003e\n\u003cp\u003eProvided as a recombinant protein suitable for in vitro workflows such as binding studies, screening, and assay development. Refer to the specifications table for expression format and molecular properties.\u003c\/p\u003e","brand":"ProSpec-Tany TechnoGene Ltd","offers":[{"title":"100 ug","offer_id":53038169686381,"sku":"pro-2494-100UG","price":165.0,"currency_code":"USD","in_stock":true},{"title":"0.5 mg","offer_id":53038518141293,"sku":"pro-2494-05MG","price":660.0,"currency_code":"USD","in_stock":true},{"title":"1 mg","offer_id":53038518174061,"sku":"pro-2494-1MG","price":1350.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/Prospecbio-caga-pylori-PRO-2494.png?v=1782158367","url":"https:\/\/www.ebiohippo.com\/products\/recombinant-helicobacter-pylori-cytotoxin-associated-gene-a-bhp11005290","provider":"BioHippo","version":"1.0","type":"link"}