{"product_id":"recombinant-hltbetar-muig-bhp14700021","title":"Recombinant hLTbetaR-muIg","description":"\u003cdiv class=\"bhp-desc\"\u003e\n\u003cstyle\u003e\n.bhp-desc{font-size:16px;color:#1a1a1a;line-height:1.7}\n.bhp-desc h2{font-size:18px;font-weight:700;color:#003366;margin:24px 0 10px;padding-bottom:6px;border-bottom:2px solid #003366}\n.bhp-desc p{margin:0 0 12px}\n.bhp-desc .bhp-spec-table{width:100%;border-collapse:collapse;margin:12px 0 18px}\n.bhp-desc .bhp-spec-table th{width:36%;text-align:left;padding:8px 12px;background:#e8f0fb;color:#003366;font-weight:600;vertical-align:top;border:1px solid #ccd9f0}\n.bhp-desc .bhp-spec-table td{padding:8px 12px;vertical-align:top;border:1px solid #ccd9f0}\n.bhp-desc .bhp-qc-badge{display:inline-block;background:#e6f4ea;color:#1a7a3c;border:1px solid #a8d5b5;border-radius:4px;padding:6px 14px;font-size:14px;font-weight:600}\n.bhp-desc .bhp-warning-box{background:#fff8e6;border-left:4px solid #e6a817;padding:10px 14px;margin:10px 0 14px;border-radius:0 4px 4px 0}\n.bhp-desc .bhp-cat-pill{display:inline-block;background:#003366;color:#fff;border-radius:20px;padding:3px 12px;font-size:13px;margin-bottom:10px}\n\u003c\/style\u003e\n\n\u003ch2\u003eScientific Background\u003c\/h2\u003e\n\u003cp\u003eHuman Lymphotoxin beta receptor (LTbR, TNFSF3) is a member of the TNF receptor superfamily with similarilty to CD120a(TNFR1) and CD120b(TNFR2). It is a expressed mainly on non lymphoid tissues(1) and appears to have an important role in secondary lymphoid organ development(5). Suppression of LTbR signaling can alleviate autoimmunity(2) or exasperate mycobacterial infection(6). Its ligands include Ltab 2 and LIGHT. In mice, LTbR signaling is important for development and function of HEV(2), Dendritic cells(3), and Mast cells(4).\u003c\/p\u003e\n\n\u003ch2\u003eProduct Description\u003c\/h2\u003e\n\u003cspan class=\"bhp-cat-pill\"\u003eCHO Cells\u003c\/span\u003e\n\u003cp\u003e\u003cstrong\u003eRecombinant hLTbetaR-muIg\u003c\/strong\u003e is a recombinant human fusion protein produced in \u003cstrong\u003eCHO Cells\u003c\/strong\u003e cells. Molecular Structure: A soluble fusion protein consisting of 10 residual amino acids from murine CD8 alpha leader sequence (KPQAPELRGS), followed by the mature extracellular (192aa) domain of human LTbR (SQPQAVP….PLEPLPP) fused to (233aa) murine IgG2a Fc (EPRGPTI….FSRTPGK). Predicted non glycosylated molecular weight of 48.9 kd.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eAlternative names:\u003c\/strong\u003e Lymphotoxinβ Receptor, Lymphotoxin beta Receptor, LTbR, TNFSF, LTbR-muIg, LTbR-Fc, LTbetaR\u003c\/p\u003e\n\n\u003ch2\u003eProtein Specifications\u003c\/h2\u003e\n\u003ctable class=\"bhp-spec-table\"\u003e\n  \u003ctr\u003e\n\u003cth\u003eFusion Format\u003c\/th\u003e\n\u003ctd\u003eMurine IgG Fc Fusion (muIg)\u003c\/td\u003e\n\u003c\/tr\u003e\n  \u003ctr\u003e\n\u003cth\u003eExpression System\u003c\/th\u003e\n\u003ctd\u003eCHO Cells\u003c\/td\u003e\n\u003c\/tr\u003e\n  \u003ctr\u003e\n\u003cth\u003eMolecular Weight\u003c\/th\u003e\n\u003ctd\u003e48.9 kDa\u003c\/td\u003e\n\u003c\/tr\u003e\n  \u003ctr\u003e\n\u003cth\u003eFormulation\u003c\/th\u003e\n\u003ctd\u003e50 mM Sodium Phosphate pH 7.5, 100 mM Potassium Chloride, 150mM NaCl, 0.5% Gentamicin sulfate\u003c\/td\u003e\n\u003c\/tr\u003e\n  \u003ctr\u003e\n\u003cth\u003eStorage\u003c\/th\u003e\n\u003ctd\u003eStore at 2 - 5°C. Freeze\/Thawing is not recommended.\u003c\/td\u003e\n\u003c\/tr\u003e\n  \u003ctr\u003e\n\u003cth\u003eSpecies Reactivity\u003c\/th\u003e\n\u003ctd\u003eHuman\u003c\/td\u003e\n\u003c\/tr\u003e\n  \u003ctr\u003e\n\u003cth\u003eValidated Applications\u003c\/th\u003e\n\u003ctd\u003eELISA\u003c\/td\u003e\n\u003c\/tr\u003e\n  \u003ctr\u003e\n\u003cth\u003eAvailable Conjugates\u003c\/th\u003e\n\u003ctd\u003eBiotin, Unconjugated\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/table\u003e\n\u003cp\u003e\u003cspan class=\"bhp-qc-badge\"\u003e✔ Research Use Only (RUO)\u003c\/span\u003e\u003c\/p\u003e\n\n\u003ch2\u003eFunctional Activity\u003c\/h2\u003e\n\u003cp\u003eRecombinant human LTbR-muIg fusion protein binds to recombinant human LIGHT in EIA.\u003c\/p\u003e\n\n\u003ch2\u003eSafety \u0026amp; Handling\u003c\/h2\u003e\n\u003cdiv class=\"bhp-warning-box\"\u003e\n\u003cp\u003e\u003cstrong\u003eResearch Use Only.\u003c\/strong\u003e Not intended for diagnostic, therapeutic, or clinical use. Handle according to good laboratory practice (GLP). Consult the Safety Data Sheet (SDS) prior to use.\u003c\/p\u003e\n\u003c\/div\u003e\n\n\u003ch2\u003eRelated Products\u003c\/h2\u003e\n\u003cp\u003eBrowse our full collection of \u003ca href=\"\/collections\/proteins\"\u003erecombinant proteins\u003c\/a\u003e and \u003ca href=\"\/collections\/antibodies\"\u003eantibodies\u003c\/a\u003e for immunology and immune checkpoint research.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Ancell Corporation","offers":[{"title":"Purified (with Antibiotic) \/ 25 ug","offer_id":53339389034861,"sku":"536-020","price":420.0,"currency_code":"USD","in_stock":true},{"title":"Purified (Preservative-free) \/ 25 ug","offer_id":53339390214509,"sku":"536-820","price":420.0,"currency_code":"USD","in_stock":true},{"title":"Biotin conjugate \/ 25 ug","offer_id":53339390247277,"sku":"536-030","price":510.0,"currency_code":"USD","in_stock":true}],"url":"https:\/\/www.ebiohippo.com\/products\/recombinant-hltbetar-muig-bhp14700021","provider":"BioHippo","version":"1.0","type":"link"}