{"product_id":"recombinant-human-a-disintegrin-and-metalloproteinase-domain-10-bhp11002783","title":"Recombinant Human A Disintegrin and Metalloproteinase Domain 10","description":"\u003cp\u003e\u003cstrong\u003eRecombinant Human A Disintegrin and Metalloproteinase Domain 10\u003c\/strong\u003e is supplied as a recombinant protein for in vitro research use.\u003c\/p\u003e\n\u003ch3\u003eBackground\u003c\/h3\u003e\n\u003cp\u003eADAM10 is part of the ADAM family which are cell surface proteins with a distinctive structure possessing both potential adhesion and protease domains. ADAM10 cleaves many proteins including TNF-alpha and E-cadherin. ADAM10 cleaves the membrane-bound precursor of tnf-alpha at 76- ala-|-val-77 to its mature soluble form. ADAM10 is in charge for the proteolytic release of several other cell-surface proteins, including ephrin-a2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein. ADAM10 is involved in the normal cleavage of the cellular prion protein. ADAM10 is involved in the cleavage of the adhesion molecule l1 at the cell surface and in the release of membrane vesicles, suggesting a vesicle-based protease activity. ADAM10 controls the proteolytic processing of notch and mediates lateral inhibition during neurogenesis.\u003c\/p\u003e\n\u003ch3\u003eProduct format\u003c\/h3\u003e\n\u003cp\u003eProvided as a recombinant protein suitable for in vitro workflows such as binding studies, screening, and assay development. Refer to the specifications table for expression format and molecular properties.\u003c\/p\u003e","brand":"ProSpec-Tany TechnoGene Ltd","offers":[{"title":"2 ug","offer_id":53038090813805,"sku":"pro-476-2UG","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10 ug","offer_id":53038365966701,"sku":"pro-476-10UG","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1 mg","offer_id":53038365999469,"sku":"pro-476-1MG","price":5200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/Prospecbio-adam10-human-PRO-476.png?v=1782158215","url":"https:\/\/www.ebiohippo.com\/products\/recombinant-human-a-disintegrin-and-metalloproteinase-domain-10-bhp11002783","provider":"BioHippo","version":"1.0","type":"link"}