{"product_id":"recombinant-human-alpha-hemoglobin-stabilizing-protein-bhp11003505","title":"Recombinant Human Alpha Hemoglobin Stabilizing Protein","description":"\u003cp\u003e\u003cstrong\u003eRecombinant Human Alpha Hemoglobin Stabilizing Protein\u003c\/strong\u003e is supplied as a recombinant protein for in vitro research use.\u003c\/p\u003e\n\u003ch3\u003eBackground\u003c\/h3\u003e\n\u003cp\u003eAlpha-hemoglobin stabilizing protein (AHSP) is an erythroid-specific protein that acts as a chaperone to prevent the aggregation of A-hemoglobin during normal erythroid cell development. AHSP specifically protects free A-hemoglobin from precipitation in live cells and in solution. AHSP is expected to modulate pathological states of alpha-hemoglobin excess such as beta-thalassemia. Furthermore, AHSP promotes alpha globin chain stability in human erythropoiesis. In addition, the AHSP stabilizes the alpha-Hb chain, thus avoiding its precipitation and its ability to generate ROS, which is implicated in cell death. AHSP is expressed in blood and bone marrow. AHSP subunit is a monomer, it forms a heterodimer with free alpha-hemoglobin. On the other hand, AHSP does not bind beta-hemoglobin nor alpha2beta2 hemoglobin A. AHSP is downregulated in TSEs (transmissible spongiform encephalopathies).\u003c\/p\u003e\n\u003ch3\u003eProduct format\u003c\/h3\u003e\n\u003cp\u003eProvided as a recombinant protein suitable for in vitro workflows such as binding studies, screening, and assay development. Refer to the specifications table for expression format and molecular properties.\u003c\/p\u003e","brand":"ProSpec-Tany TechnoGene Ltd","offers":[{"title":"10 ug","offer_id":53038113849709,"sku":"pro-720-10UG","price":60.0,"currency_code":"USD","in_stock":true},{"title":"50 ug","offer_id":53038410498413,"sku":"pro-720-50UG","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1 mg","offer_id":53038410531181,"sku":"pro-720-1MG","price":1800.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/Prospecbio-ahsp-human-PRO-720.png?v=1782158265","url":"https:\/\/www.ebiohippo.com\/products\/recombinant-human-alpha-hemoglobin-stabilizing-protein-bhp11003505","provider":"BioHippo","version":"1.0","type":"link"}