{"product_id":"recombinant-human-centromere-protein-b-bhp11003056","title":"Recombinant Human Centromere Protein-B","description":"\u003cp\u003e\u003cstrong\u003eRecombinant Human Centromere Protein-B\u003c\/strong\u003e is supplied as a recombinant protein for in vitro research use.\u003c\/p\u003e\n\u003ch3\u003eBackground\u003c\/h3\u003e\n\u003cp\u003eCentromere proteins are a group of proteins which form and\/or mediate the function of centromeres, the central structures of chromosomes to which spindle fibers\/microtubuli attach and pull the chromosomes apart in cell division. Currently, 9 centromere proteins are known and designated CENPA to CENP-I. Most of the centromere proteins are targets of autoantibodies, the anti-centromere antibodies. CENPB is the most important of the centromeric autoantigens: it has a molecular weight of approx. 66 kDa and plays an important role in the formation of the centromeric chromatin. CENPB antibodies are present in the sera of up to 80% of patients with CREST syndrome.\u003c\/p\u003e\n\u003ch3\u003eProduct format\u003c\/h3\u003e\n\u003cp\u003eProvided as a recombinant protein suitable for in vitro workflows such as binding studies, screening, and assay development. Refer to the specifications table for expression format and molecular properties.\u003c\/p\u003e\n\u003ch3\u003eActivity \u0026amp; assay information\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eCoating concentration:\u003c\/strong\u003e 0.15-0.375 µg\/ml (depending on the type of ELISA plate and coating buffer). Suitable for biotinylation and iodination.\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"ProSpec-Tany TechnoGene Ltd","offers":[{"title":"5 ug","offer_id":53038100119917,"sku":"pro-390-5UG","price":60.0,"currency_code":"USD","in_stock":true},{"title":"20 ug","offer_id":53038382743917,"sku":"pro-390-20UG","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1 mg","offer_id":53038382776685,"sku":"pro-390-1MG","price":5200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/Prospecbio-cenpb-human-PRO-390.png?v=1782158237","url":"https:\/\/www.ebiohippo.com\/products\/recombinant-human-centromere-protein-b-bhp11003056","provider":"BioHippo","version":"1.0","type":"link"}