{"product_id":"recombinant-human-chromosome-12-open-reading-frame-5-tat-bhp11005027","title":"Recombinant Human Chromosome 12 Open Reading Frame 5-TAT","description":"\u003cp\u003e\u003cstrong\u003eRecombinant Human Chromosome 12 Open Reading Frame 5-TAT\u003c\/strong\u003e is supplied as a recombinant protein for in vitro research use.\u003c\/p\u003e\n\u003ch3\u003eBackground\u003c\/h3\u003e\n\u003cp\u003eTIGAR is a p53-inducible enzyme which catalyzes the hydrolysis of fructose-2-6 bisphosphate (F-2-6-BP) to fructose-6-phosphate and inorganic phosphate. F-2-6-BP is an influential activator of 6-phosphofructose-1 kinase (the rate limiting enzyme of glycolysis). By lowering the intracellular level of F-2-6-BP, TIGAR expression leads to increased glucose processing through the pentose phosphate pathway, the main cellular source for NADPH. Protein transduction using TAT fusion proteins represents an alternative methodology for introducing transcription factors and other intracellular proteins into primary as well as transformed cells.\u003c\/p\u003e\n\u003ch3\u003eProduct format\u003c\/h3\u003e\n\u003cp\u003eProvided as a recombinant protein suitable for in vitro workflows such as binding studies, screening, and assay development. Refer to the specifications table for expression format and molecular properties.\u003c\/p\u003e","brand":"ProSpec-Tany TechnoGene Ltd","offers":[{"title":"5 ug","offer_id":53038164902253,"sku":"pro-1580-5UG","price":60.0,"currency_code":"USD","in_stock":true},{"title":"25 ug","offer_id":53038508900717,"sku":"pro-1580-25UG","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1 mg","offer_id":53038508933485,"sku":"pro-1580-1MG","price":2700.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/Prospecbio-tigar-human-tat-PRO-1580.png?v=1782158360","url":"https:\/\/www.ebiohippo.com\/products\/recombinant-human-chromosome-12-open-reading-frame-5-tat-bhp11005027","provider":"BioHippo","version":"1.0","type":"link"}