{"product_id":"recombinant-human-coagulation-factor-viii-bhp11003098","title":"Recombinant Human Coagulation Factor VIII","description":"\u003cp\u003e\u003cstrong\u003eRecombinant Human Coagulation Factor VIII\u003c\/strong\u003e is supplied as a recombinant protein for in vitro research use.\u003c\/p\u003e\n\u003ch3\u003eBackground\u003c\/h3\u003e\n\u003cp\u003eCoagulation factor VIII participates in the intrinsic pathway of blood coagulation; factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder.\u003c\/p\u003e\n\u003ch3\u003eProduct format\u003c\/h3\u003e\n\u003cp\u003eProvided as a recombinant protein suitable for in vitro workflows such as binding studies, screening, and assay development. Refer to the specifications table for expression format and molecular properties.\u003c\/p\u003e","brand":"ProSpec-Tany TechnoGene Ltd","offers":[{"title":"250 IU","offer_id":53038101528941,"sku":"pro-318-250IU","price":1320.0,"currency_code":"USD","in_stock":true},{"title":"500 IU","offer_id":53038385168749,"sku":"pro-318-500IU","price":2420.0,"currency_code":"USD","in_stock":true},{"title":"1000 IU","offer_id":53038385201517,"sku":"pro-318-1000IU","price":4125.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/Prospecbio-factor-viii-human-recombinant-PRO-318.png?v=1782158237","url":"https:\/\/www.ebiohippo.com\/products\/recombinant-human-coagulation-factor-viii-bhp11003098","provider":"BioHippo","version":"1.0","type":"link"}