{"product_id":"recombinant-human-colony-stimulating-factor-1-receptor-bhp11005711","title":"Recombinant Human Colony Stimulating Factor 1 Receptor","description":"\u003cp\u003e\u003cstrong\u003eRecombinant Human Colony Stimulating Factor 1 Receptor\u003c\/strong\u003e is supplied as a recombinant protein for in vitro research use.\u003c\/p\u003e\n\u003ch3\u003eBackground\u003c\/h3\u003e\n\u003cp\u003eMCSFR which is also familiar as CSF1R, is part of the type3 subfamily of receptor tyrosine kinases. MCSFR is expressed mainly on cells of the monocyte and macrophage lineage, stem cells, and in the growing placenta. Most of the biological effects of this cytokine are mediated by MCSFR. MCSFR contains an extracellular ligand-binding domain, a single membrane-spanning segment, and an intracellular tyrosine kinase domain. Originally CSF1 and this receptor were implicated as vital for normal trophoblastic implantation as well as monocyte development. The role of CSF1\/CSF1R in normal mammary gland development is actually very interesting since this connection has also been discovered in the biology of breast cancer with the results of abnormal expression of CSF1 and its receptor. Likewise, in Alzheimer's disease and after brain injuries an increased level of CSF1R was found in the microglia, which causes the microglia to become more active.\u003c\/p\u003e\n\u003ch3\u003eProduct format\u003c\/h3\u003e\n\u003cp\u003eProvided as a recombinant protein suitable for in vitro workflows such as binding studies, screening, and assay development. Refer to the specifications table for expression format and molecular properties.\u003c\/p\u003e","brand":"ProSpec-Tany TechnoGene Ltd","offers":[{"title":"1 ug","offer_id":53038172045677,"sku":"cyt-1068-1UG","price":100.0,"currency_code":"USD","in_stock":true},{"title":"5 ug","offer_id":53038523580781,"sku":"cyt-1068-5UG","price":300.0,"currency_code":"USD","in_stock":true},{"title":"50 ug","offer_id":53038523613549,"sku":"cyt-1068-50UG","price":1200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/Prospecbio-csf1r-human-CYT-1068.png?v=1782158375","url":"https:\/\/www.ebiohippo.com\/products\/recombinant-human-colony-stimulating-factor-1-receptor-bhp11005711","provider":"BioHippo","version":"1.0","type":"link"}