{"product_id":"recombinant-human-cop9-signalosome-subunit-7a-bhp11003146","title":"Recombinant Human COP9 Signalosome Subunit 7A","description":"\u003cp\u003e\u003cstrong\u003eRecombinant Human COP9 Signalosome Subunit 7A\u003c\/strong\u003e is supplied as a recombinant protein for in vitro research use.\u003c\/p\u003e\n\u003ch3\u003eBackground\u003c\/h3\u003e\n\u003cp\u003eCOP9 Signalosome Subunit 7A (COPS7A) is a component of the COP9 signalosome complex (CSN), a complex involved in a variety of cellular and developmental processes. The CSN complex is a vital regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, thus leading to decrease in the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. This complex is also involved in phosphorylation of p53\/TP53, JUN, I-kappa-B-alpha\/NFKBIA, ITPK1 and IRF8\/ICSBP, probably through its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN stimulates and protects degradation by the Ubl system, respectively.\u003c\/p\u003e\n\u003ch3\u003eProduct format\u003c\/h3\u003e\n\u003cp\u003eProvided as a recombinant protein suitable for in vitro workflows such as binding studies, screening, and assay development. Refer to the specifications table for expression format and molecular properties.\u003c\/p\u003e","brand":"ProSpec-Tany TechnoGene Ltd","offers":[{"title":"5 ug","offer_id":53038103953773,"sku":"pro-1947-5UG","price":60.0,"currency_code":"USD","in_stock":true},{"title":"20 ug","offer_id":53038387921261,"sku":"pro-1947-20UG","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1 mg","offer_id":53038387954029,"sku":"pro-1947-1MG","price":2700.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/Prospecbio-cops7a-human-PRO-1947.png?v=1782158243","url":"https:\/\/www.ebiohippo.com\/products\/recombinant-human-cop9-signalosome-subunit-7a-bhp11003146","provider":"BioHippo","version":"1.0","type":"link"}