{"product_id":"recombinant-human-corticotropin-releasing-hormone-146-196-a-a-bhp11006483","title":"Recombinant Human Corticotropin Releasing Hormone (146-196 a.a.)","description":"\u003cp\u003e\u003cstrong\u003eRecombinant Human Corticotropin Releasing Hormone (146-196 a.a.)\u003c\/strong\u003e is supplied as a recombinant protein for in vitro research use.\u003c\/p\u003e\n\u003ch3\u003eBackground\u003c\/h3\u003e\n\u003cp\u003eCRH is a neuropeptide which regulates body's response to stress. CRH takes part in the hypothalamic-pituitary-adrenal axis which controls the production of cortisol and other glucocorticoids. CRH is synthesized in different tissues such as the brainstem, hypothalamus and peripheral organs. In Pregnancy, CRH regulates parturition and fetal development. CRH binds 2 types of receptors- CRH receptor 1 and CRH receptor 2, both are G-protein-coupled receptors (GPCRs). After binding CRHR1, CRH initiates a cascade of intracellular signalling which leads to the release of ACTH from the anterior pituitary. This release stimulates cortisol secretion from the adrenal glands, which is necessary for controlling the body's stress response and maintain energy balance and immune function.\u003c\/p\u003e\n\u003ch3\u003eProduct format\u003c\/h3\u003e\n\u003cp\u003eProvided as a recombinant protein suitable for in vitro workflows such as binding studies, screening, and assay development. Refer to the specifications table for expression format and molecular properties.\u003c\/p\u003e","brand":"ProSpec-Tany TechnoGene Ltd","offers":[{"title":"50 ug","offer_id":53038188429677,"sku":"hor-055-50UG","price":200.0,"currency_code":"USD","in_stock":true},{"title":"100 ug","offer_id":53038563295597,"sku":"hor-055-100UG","price":300.0,"currency_code":"USD","in_stock":true},{"title":"1 mg","offer_id":53038563328365,"sku":"hor-055-1MG","price":1500.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/Prospecbio-crf-human-HOR-055.png?v=1782158404","url":"https:\/\/www.ebiohippo.com\/products\/recombinant-human-corticotropin-releasing-hormone-146-196-a-a-bhp11006483","provider":"BioHippo","version":"1.0","type":"link"}