{"product_id":"recombinant-human-dickkopf-related-protein-1-bhp11003246","title":"Recombinant Human Dickkopf-Related Protein 1","description":"\u003cp\u003e\u003cstrong\u003eRecombinant Human Dickkopf-Related Protein 1\u003c\/strong\u003e is supplied as a recombinant protein for in vitro research use.\u003c\/p\u003e\n\u003ch3\u003eBackground\u003c\/h3\u003e\n\u003cp\u003eDickkopf-related protein 1 (DKK1) antagonizes canonical Wnt signaling by inhibiting LRP5\/6 interaction with Wnt and by creating a ternary complex with the transmembrane protein KREMEN which promotes internalization of LRP5\/6. DKKs have a significant role in vertebrate development, where they locally inhibit Wnt controlled processes for instance antero-posterior axial patterning, limb development, somitogenesis and eye formation. Furthermore, Dkks are involved in bone formation and bone disease, cancer and Alzheimer disease in Adults.\u003c\/p\u003e\n\u003ch3\u003eProduct format\u003c\/h3\u003e\n\u003cp\u003eProvided as a recombinant protein suitable for in vitro workflows such as binding studies, screening, and assay development. Refer to the specifications table for expression format and molecular properties.\u003c\/p\u003e","brand":"ProSpec-Tany TechnoGene Ltd","offers":[{"title":"5 ug","offer_id":53038106083693,"sku":"pro-1566-5UG","price":60.0,"currency_code":"USD","in_stock":true},{"title":"20 ug","offer_id":53038393786733,"sku":"pro-1566-20UG","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1 mg","offer_id":53038393819501,"sku":"pro-1566-1MG","price":2700.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/Prospecbio-human-dkk1-PRO-1566.png?v=1782158246","url":"https:\/\/www.ebiohippo.com\/products\/recombinant-human-dickkopf-related-protein-1-bhp11003246","provider":"BioHippo","version":"1.0","type":"link"}