{"product_id":"recombinant-human-endoglin-bhp11000427","title":"Recombinant Human Endoglin","description":"\u003cp\u003e\u003cstrong\u003eRecombinant Human Endoglin\u003c\/strong\u003e is supplied as a recombinant protein for in vitro research use.\u003c\/p\u003e\n\u003ch3\u003eBackground\u003c\/h3\u003e\n\u003cp\u003eEndoglin is a type I membrane glycoprotein located on cell surfaces and is part of the TGF beta receptor complex. The Endoglin protein consists of a homodimer of 180 kDA with disulfide links. Endoglin has been found on endothelial cells, activated macrophages, fibroblasts, and smooth muscle cells. Furthermore, Endoglin has been found to be part of the TGF-beta1 receptor complex. Endoglin thus may be involved in the binding of TGF-beta1, TGF-beta3, activin-A, BMP-2, and BMP-7. Beside TGF-beta signaling endoglin may have other functions. It has been postulated that endoglin is involved in the cytoskeletal organization affecting cell morphology and migration. Endoglin has a role in the development of the cardiovascular system and in vascular remodeling. Endoglin expression is regulated during heart development . Experimental mice without the endoglin gene die due to cardiovascular abnormalities.\u003c\/p\u003e\n\u003ch3\u003eProduct format\u003c\/h3\u003e\n\u003cp\u003eProvided as a recombinant protein suitable for in vitro workflows such as binding studies, screening, and assay development. Refer to the specifications table for expression format and molecular properties.\u003c\/p\u003e","brand":"ProSpec-Tany TechnoGene Ltd","offers":[{"title":"2 ug","offer_id":53038051033453,"sku":"cyt-525-2UG","price":175.0,"currency_code":"USD","in_stock":true},{"title":"5 ug","offer_id":53038285128045,"sku":"cyt-525-5UG","price":270.0,"currency_code":"USD","in_stock":true},{"title":"10 ug","offer_id":53038285160813,"sku":"cyt-525-10UG","price":490.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/Prospecbio-endoglin-human-CYT-525.png?v=1782158130","url":"https:\/\/www.ebiohippo.com\/products\/recombinant-human-endoglin-bhp11000427","provider":"BioHippo","version":"1.0","type":"link"}