{"product_id":"recombinant-human-exosome-component-10-bhp11003332","title":"Recombinant Human Exosome Component 10","description":"\u003cp\u003e\u003cstrong\u003eRecombinant Human Exosome Component 10\u003c\/strong\u003e is supplied as a recombinant protein for in vitro research use.\u003c\/p\u003e\n\u003ch3\u003eBackground\u003c\/h3\u003e\n\u003cp\u003eEXOSC10 is a nucleolar protein and represents one crucial component of the so-called \"PM\/Scl complex\" or \"nuclear exosome\", which is an RNA-processing complex consisting of a number of exoribonucleases (not to be confused with certain multivesicular bodies which are shed by cultured cells into the culture fluid and are also called exosomes). Autoantibodies against EXOSC10 occur in patients suffering from polymyositis, scleroderma or polymyositis\/scleroderma overlap syndromes. While antibodies to other components of the exosome complex (PM\/Scl 75, several Rrp proteins) can be found in some sera, practically all patients with autoantibodies against the PM\/Scl complex are positive for EXOSC10 antibodies, making this specificity an important marker. The presence of EXOSC10 autoantibodies is a comparatively \"good\" prognostic sign in polymyositis\/scleroderma overlap syndrome unlike the poor prognosis seen when other myositis and systemic sclerosis specific autoantibodies are present.\u003c\/p\u003e\n\u003ch3\u003eProduct format\u003c\/h3\u003e\n\u003cp\u003eProvided as a recombinant protein suitable for in vitro workflows such as binding studies, screening, and assay development. Refer to the specifications table for expression format and molecular properties.\u003c\/p\u003e\n\u003ch3\u003eActivity \u0026amp; assay information\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunological functions:\u003c\/strong\u003e 1. Binds IgG-type human auto-antibodies.\u003cbr\u003e2. Standard ELISA test (checker-board analysis of positive\/negative sera panels).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCoating concentration:\u003c\/strong\u003e 0.4-0.8 µg\/ml (depending on the type of ELISA plate and coating buffer). Suitable for biotinylation and iodination.\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"ProSpec-Tany TechnoGene Ltd","offers":[{"title":"5 ug","offer_id":53038109393261,"sku":"pro-444-5UG","price":60.0,"currency_code":"USD","in_stock":true},{"title":"20 ug","offer_id":53038399816045,"sku":"pro-444-20UG","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1 mg","offer_id":53038399848813,"sku":"pro-444-1MG","price":5200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/Prospecbio-exosc10-human-PRO-444.png?v=1782158255","url":"https:\/\/www.ebiohippo.com\/products\/recombinant-human-exosome-component-10-bhp11003332","provider":"BioHippo","version":"1.0","type":"link"}