{"product_id":"recombinant-human-glycoprotein-nmb-bhp11003404","title":"Recombinant Human Glycoprotein Nmb","description":"\u003cp\u003e\u003cstrong\u003eRecombinant Human Glycoprotein Nmb\u003c\/strong\u003e is supplied as a recombinant protein for in vitro research use.\u003c\/p\u003e\n\u003ch3\u003eBackground\u003c\/h3\u003e\n\u003cp\u003eGlycoprotein Nmb (GPNMB) is a member of the PMEL\/NMB family. GPNMB is a type I transmembrane glycoprotein which exhibits homology to the pMEL17 precursor, a melanocyte-specific protein. GPNMB is expressed in the lowly metastatic human melanoma cell lines and xenografts but has no expression in the highly metastatic cell lines. GPNMB might be involved in growth delay and reduction of metastatic potential. GPNMB is up-regulated in a number of cancer cells, including in glioblastoma multiforme. GPNMB is expressed in many melanoma cells, as well as in tissue macrophages, including liver Kuppfer cells and lung alveolar macrophages, in podocytes and in some cells of the ciliary body of the eye (at protein level). GPNMB is hardly detectable in the healthy brain.\u003c\/p\u003e\n\u003ch3\u003eProduct format\u003c\/h3\u003e\n\u003cp\u003eProvided as a recombinant protein suitable for in vitro workflows such as binding studies, screening, and assay development. Refer to the specifications table for expression format and molecular properties.\u003c\/p\u003e","brand":"ProSpec-Tany TechnoGene Ltd","offers":[{"title":"5 ug","offer_id":53038110835053,"sku":"pro-1666-5UG","price":60.0,"currency_code":"USD","in_stock":true},{"title":"20 ug","offer_id":53038404600173,"sku":"pro-1666-20UG","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1 mg","offer_id":53038404632941,"sku":"pro-1666-1MG","price":2700.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/Prospecbio-gpnmb-human-PRO-1666.png?v=1782158260","url":"https:\/\/www.ebiohippo.com\/products\/recombinant-human-glycoprotein-nmb-bhp11003404","provider":"BioHippo","version":"1.0","type":"link"}