{"product_id":"recombinant-human-growth-arrest-and-dna-damage-inducible-beta-bhp11003255","title":"Recombinant Human Growth Arrest and DNA-Damage-Inducible Beta","description":"\u003cp\u003e\u003cstrong\u003eRecombinant Human Growth Arrest and DNA-Damage-Inducible Beta\u003c\/strong\u003e is supplied as a recombinant protein for in vitro research use.\u003c\/p\u003e\n\u003ch3\u003eBackground\u003c\/h3\u003e\n\u003cp\u003eGADD45B is part of the nuclear proteins to interact with various proteins whose transcript levels are raised after stressful growth arrest conditions and treatment with DNA-damaging agents. GADD45B reacts to environmental stresses by mediating activation of the p38\/JNK pathway which is mediated through their protein binding and activating MTK1\/MEKK4 kinase, which is an upstream activator of both p38 and JNK MAPKs. GADD45B is involved in the regulation of growth and apoptosis. GADD45b takes part during chondrocyte terminal differentiation and mediates MMP-13 gene expression. GADD45 in B cells is induced by CD40 via a mechanism that involves NF-kappa B and that induction suppresses Fas-mediated killing. GADD45b is down-regulated in most cases of hepatocellular carcinoma (HCC), and is a molecular marker in the diagnosis of HCC and as a possible therapeutic target.\u003c\/p\u003e\n\u003ch3\u003eProduct format\u003c\/h3\u003e\n\u003cp\u003eProvided as a recombinant protein suitable for in vitro workflows such as binding studies, screening, and assay development. Refer to the specifications table for expression format and molecular properties.\u003c\/p\u003e","brand":"ProSpec-Tany TechnoGene Ltd","offers":[{"title":"10 ug","offer_id":53038106575213,"sku":"pro-563-10UG","price":60.0,"currency_code":"USD","in_stock":true},{"title":"50 ug","offer_id":53038394769773,"sku":"pro-563-50UG","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1 mg","offer_id":53038394802541,"sku":"pro-563-1MG","price":1800.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/Prospecbio-gadd45b-human-PRO-563.png?v=1782158248","url":"https:\/\/www.ebiohippo.com\/products\/recombinant-human-growth-arrest-and-dna-damage-inducible-beta-bhp11003255","provider":"BioHippo","version":"1.0","type":"link"}