{"product_id":"recombinant-human-growth-hormone-binding-protein-bhp11002324","title":"Recombinant Human Growth Hormone Binding Protein","description":"\u003cp\u003e\u003cstrong\u003eRecombinant Human Growth Hormone Binding Protein\u003c\/strong\u003e is supplied as a recombinant protein for in vitro research use.\u003c\/p\u003e\n\u003ch3\u003eBackground\u003c\/h3\u003e\n\u003cp\u003eGHBP is a transmembrane receptor for GH. Binding of GH to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. A common alternate allele of this gene, called GHRd3, lacks exon three and has been well-characterized. Mutations in this gene have been associated with Laron syndrome, also known as the GH insensitivity syndrome (GHIS), a disorder characterized by short stature. Other splice variants, including one encoding a soluble form of the protein (GHRtr), have been observed but have not been thoroughly characterized.\u003c\/p\u003e\n\u003ch3\u003eProduct format\u003c\/h3\u003e\n\u003cp\u003eProvided as a recombinant protein suitable for in vitro workflows such as binding studies, screening, and assay development. Refer to the specifications table for expression format and molecular properties.\u003c\/p\u003e\n\u003ch3\u003eQuality notes\u003c\/h3\u003e\n\u003cp\u003eProtein quantitation was carried out by two independent methods:\u003cbr\u003e1. UV spectroscopy at 280 nm using the absorbency value of 2.6 as the extinction coefficient for a 0.1% (1mg\/ml) solution. This value is calculated by the PC GENE computer analysis program of protein sequences (IntelliGenetics).\u003cbr\u003e2. Analysis by RP-HPLC, using a calibrated solution of GHBP as a Reference Standard.\u003c\/p\u003e","brand":"ProSpec-Tany TechnoGene Ltd","offers":[{"title":"5 ug","offer_id":53038077739373,"sku":"cyt-238-5UG","price":60.0,"currency_code":"USD","in_stock":true},{"title":"20 ug","offer_id":53038337425773,"sku":"cyt-238-20UG","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1 mg","offer_id":53038337458541,"sku":"cyt-238-1MG","price":5200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/Prospecbio-ghbp-human-CYT-238.png?v=1782158189","url":"https:\/\/www.ebiohippo.com\/products\/recombinant-human-growth-hormone-binding-protein-bhp11002324","provider":"BioHippo","version":"1.0","type":"link"}