{"product_id":"recombinant-human-heat-shock-transcription-factor-1-bhp11003446","title":"Recombinant Human Heat Shock Transcription Factor-1","description":"\u003cp\u003e\u003cstrong\u003eRecombinant Human Heat Shock Transcription Factor-1\u003c\/strong\u003e is supplied as a recombinant protein for in vitro research use.\u003c\/p\u003e\n\u003ch3\u003eBackground\u003c\/h3\u003e\n\u003cp\u003eThe transcription of heat-shock genes is rapidly induced after temperature stress in response to environmental changes, and it is also involved in oogenesis, spermatogenesis, and placental development. Hsp90, is a major repressor of HSF1 gene. HSF1 is known for its participation in heat shock response. HSF1 protein regulates the transcription of hundreds of targets, such as genes involved in protein folding, detoxification, energy generation, carbohydrate metabolism, and cell wall organization. HSF1 binds to MTA1 in vitro \u0026amp; in breast carcinoma. Suppression of estrogen-dependent transcription may contribute to role of HSF1 in cancer. Human cancer lines of diverse origins express higher dependence on HSF1 function to maintain proliferation and survival than their non-transformed counterparts. HSF1 induces anticoagulation and relaxation factors in vascular endothelial cells and could therefore be used to treat cardiovascular disease. HSF1 is directly involved in the regulation of HO1 having an anti-oxidative role. NF-kappaB and HSF1 are systemically activated in human acute pancreatitis. HSF1 activation protects against severity of pancreatitis. HSF is a vital transcription factor which plays a role in up-regulation of VDUP1 expression through stresses such as elevated density and serum deprivation cultures.\u003c\/p\u003e\n\u003ch3\u003eProduct format\u003c\/h3\u003e\n\u003cp\u003eProvided as a recombinant protein suitable for in vitro workflows such as binding studies, screening, and assay development. Refer to the specifications table for expression format and molecular properties.\u003c\/p\u003e","brand":"ProSpec-Tany TechnoGene Ltd","offers":[{"title":"5 ug","offer_id":53038112866669,"sku":"hsp-017-5UG","price":60.0,"currency_code":"USD","in_stock":true},{"title":"25 ug","offer_id":53038407221613,"sku":"hsp-017-25UG","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1 mg","offer_id":53038407254381,"sku":"hsp-017-1MG","price":3600.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/Prospecbio-hsf1-human-HSP-017.png?v=1782158261","url":"https:\/\/www.ebiohippo.com\/products\/recombinant-human-heat-shock-transcription-factor-1-bhp11003446","provider":"BioHippo","version":"1.0","type":"link"}