{"product_id":"recombinant-human-hepatitis-a-virus-cellular-receptor-2-havcr2-partial-bhp10508831","title":"Recombinant Human Hepatitis A virus cellular receptor 2 (HAVCR2), partial","description":"\u003ch2\u003eOverview\u003c\/h2\u003e \u003cp\u003eRecombinant Human Hepatitis A virus cellular receptor 2 (HAVCR2), partial is a recombinant protein reagent derived from Homo sapiens (Human) and produced in Mammalian cell. It is commonly used to support Immunology research by enabling binding assays, assay development and protein–protein interaction studies in controlled in vitro settings.\u003c\/p\u003e \u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e \u003cli\u003e\n\u003cstrong\u003eExpressed region:\u003c\/strong\u003e 20-200aa. Region selection can focus on functional domains, improve solubility, or isolate interaction surfaces for targeted studies.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eExpression system:\u003c\/strong\u003e Mammalian cell. Expression host can influence folding and the presence\/absence of post-translational modifications.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eTag \/ fusion:\u003c\/strong\u003e C-terminal hFc1-tagged. Tags can support purification and detection; evaluate potential tag effects when studying sensitive interactions.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eMolecular weight (reported):\u003c\/strong\u003e 48.9 kDa. Apparent size may vary with tags, processing, and gel conditions.\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eWhen comparing results across batches or platforms, interpret signals in the context of construct design (region, tags) and expression host, especially for modification-dependent interactions.\u003c\/p\u003e \u003ch2\u003eBiological background\u003c\/h2\u003e \u003cp\u003eThe gene commonly associated with this target is \u003cstrong\u003eHAVCR2\u003c\/strong\u003e. HAVCR2 refers to a protein target that is studied across multiple biological contexts; annotations and nomenclature can vary by species and isoform. This product corresponds to the Homo sapiens (Human) sequence context, which can be important when comparing homologs or orthologs across model systems. For curated functional annotations, domains, and sequence features, consult primary databases (e.g., UniProt\/NCBI) and the recent literature for the specific organism and isoform.\u003c\/p\u003e \u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e \u003cli\u003eProfiling immune signaling nodes and cytokine pathways across cell types and activation states.\u003c\/li\u003e \u003cli\u003eStudying ligand–receptor interactions that shape immune cell communication and effector function.\u003c\/li\u003e \u003cli\u003eBuilding quantitative assays to compare pathway modulation by genetic or pharmacologic perturbations.\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003e\u003cstrong\u003eRelevance:\u003c\/strong\u003e Cell surface receptor implicated in modulating innate and adaptive immune responses. Generally accepted to have an inhibiting function. Reports on stimulating functions suggest that the activity may be influenced by the cellular context and\/or the respective ligand . Regulates macrophage activation . Inhibits T-helper type 1 lymphocyte -mediated auto- and alloimmune responses and promotes immunological tolerance . In CD8+ cells attenuates TCR-induced signaling, specifically by blocking NF-kappaB and NFAT promoter activities resulting in the loss of IL-2 secretion. The function may implicate its association with LCK proposed to impair phosphorylation of TCR subunits, and\/or LGALS9-dependent recruitment of PTPRC to the immunological synapse . In contrast, shown to activate TCR-induced signaling in T-cells probably implicating ZAP70, LCP2, LCK and FYN . Expressed on Treg cells can inhibit Th17 cell responses . Receptor for LGALS9 . Binding to LGALS9 is believed to result in suppression of T-cell responses; the resulting apoptosis of antigen-specific cells may implicate HAVCR2 phosphorylation and disruption of its association with BAG6. Binding to LGALS9 is proposed to be involved in innate immune response to intracellular pathogens. Expressed on Th1 cells interacts with LGALS9 expressed on Mycobacterium tuberculosis-infected macrophages to stimulate antibactericidal activity including IL-1 beta secretion and to restrict intracellular bacterial growth . However, the function as receptor for LGALS9 has been challenged . Also reported to enhance CD8+ T-cell responses to an acute infection such as by Listeria monocytogenes . Receptor for phosphatidylserine; PtSer-binding is calcium-dependent. May recognize PtSer on apoptotic cells leading to their phagocytosis. Mediates the engulfment of apoptotic cells by dendritic cells. Expressed on T-cells, promotes conjugation but not engulfment of apoptotic cells. Expressed on dendritic cells positively regulates innate immune response and in synergy with Toll-like receptors promotes secretion of TNF-alpha. In tumor-imfiltrating DCs suppresses nucleic acid-mediated innate immune repsonse by interaction with HMGB1 and interfering with nucleic acid-sensing and trafficking of nucleid acids to endosomes . Expressed on natural killer cells acts as a coreceptor to enhance IFN-gamma production in response to LGALS9 . In contrast, shown to suppress NK cell-mediated cytotoxicity . Negatively regulates NK cell function in LPS-induced endotoxic shock .\u003c\/p\u003e \u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e \u003cli\u003eAssay and standard development for immunoassays or binding-based detection methods.\u003c\/li\u003e \u003cli\u003eProtein–protein interaction studies (e.g., receptor–ligand or complex assembly) using purified components.\u003c\/li\u003e \u003cli\u003eStructure–function analysis, including domain mapping or evaluation of sequence variants.\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eIn quantitative assay development, changes in binding or activity readouts are typically interpreted relative to appropriate negative\/positive controls and, where possible, orthogonal assay formats that support the same conclusion.\u003c\/p\u003e \u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e \u003cli\u003eRecombinant constructs may represent a defined region (domain) rather than the full-length protein; interpret results in the context of the expressed region.\u003c\/li\u003e \u003cli\u003eTag or fusion elements can aid purification and detection but may influence binding surfaces or oligomerization; consider tag controls when relevant.\u003c\/li\u003e \u003cli\u003eSpecies and isoform differences can affect interaction partners and post-translational modifications; align experimental controls to the intended biological context.\u003c\/li\u003e \u003c\/ul\u003e \u003c!-- Sources (internal): - UniProtKB entry for Q8TDQ0 — UniProt — https:\/\/www.uniprot.org\/uniprotkb\/Q8TDQ0\/entry - NCBI Gene search (HAVCR2) — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=HAVCR2 - PubMed search (HAVCR2) — NCBI — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=HAVCR2 - RCSB PDB search (HAVCR2) — RCSB PDB — https:\/\/www.rcsb.org\/search?query=HAVCR2 - Reactome Pathway Browser — Reactome — https:\/\/reactome.org\/ --\u003e","brand":"CUSABIO TECHNOLOGY LLC","offers":[{"title":"1 mg","offer_id":53065269739885,"sku":"CSB-MP010145HU1-1MG","price":2264.0,"currency_code":"USD","in_stock":true},{"title":"100 ug","offer_id":53065385509229,"sku":"CSB-MP010145HU1-100UG","price":344.0,"currency_code":"USD","in_stock":true},{"title":"20 ug","offer_id":53065385541997,"sku":"CSB-MP010145HU1-20UG","price":138.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/CSB-MP010145HU-SDS.jpg?v=1772476400","url":"https:\/\/www.ebiohippo.com\/products\/recombinant-human-hepatitis-a-virus-cellular-receptor-2-havcr2-partial-bhp10508831","provider":"BioHippo","version":"1.0","type":"link"}