{"product_id":"recombinant-human-igfbp5-protein-n-his-sumo-and-c-strep-bhp21400021","title":"Recombinant Human IGFBP5 Protein, N-His-SUMO\u0026C-Strep","description":"\u003ch2\u003eBackground\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eWhat is IGFBP5?\u003c\/strong\u003e Insulin-like growth factor-binding protein 5 (IGFBP5) is a Secreted IGF-binding protein that modulates IGF bioavailability and signaling context. This target is supplied here as a \u003cstrong\u003erecombinant protein reagent for research use only\u003c\/strong\u003e, enabling controlled biochemical and cell-free interrogation of binding, activity, and interaction logic with a traceable input material.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSubcellular localization (research context):\u003c\/strong\u003e Secreted\/extracellular; can associate with extracellular matrix components.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eDomain \/ architecture (why fragments matter):\u003c\/strong\u003e An IGFBP N-terminal domain and C-terminal domain linked by a variable region; disulfide bonds contribute to stability.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eWhat this recombinant protein represents:\u003c\/strong\u003e This product is a \u003cstrong\u003erecombinant Human IGFBP5\u003c\/strong\u003e protein  corresponding to \u003cstrong\u003eCys30-Glu121\u003c\/strong\u003e with a \u003cstrong\u003eN-His; SUMO; C-Strep\u003c\/strong\u003e tag. It is expressed in \u003cstrong\u003eE. coli\u003c\/strong\u003e and supplied as a purified RUO reagent.\u003c\/p\u003e\n\n\u003chr\u003e\n\n\u003ch2\u003eBiological significance and function\u003c\/h2\u003e\n\u003cp\u003eIGFBP5 is used in growth factor signaling research to dissect how binding proteins tune IGF ligand distribution, receptor engagement, and context-dependent signaling outputs. Recombinant IGFBP5 enables controlled binding and competition studies.\u003c\/p\u003e\n\n\u003chr\u003e\n\n\u003ch2\u003eMolecular characteristics relevant to experimental design\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eProtein class:\u003c\/strong\u003e Secreted IGF-binding protein that modulates IGF bioavailability and signaling context\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eRegion \/ construct:\u003c\/strong\u003e Cys30-Glu121\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApprox. molecular weight:\u003c\/strong\u003e 23.83 kDa\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eForm:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e \u0026gt;90%\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurification:\u003c\/strong\u003e Affinity-chromatography\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003ePost-translational and conformational considerations:\u003c\/strong\u003e Prokaryotic expression typically yields a non-glycosylated recombinant form. This is often appropriate for cytosolic enzymes and many binding studies, while secreted or multi-domain extracellular targets can behave differently when native PTMs are required.\u003c\/p\u003e\n\n\u003chr\u003e\n\n\u003ch2\u003eExpression and purification context (quality transparency for RUO)\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eExpression system:\u003c\/strong\u003e E. coli\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eRegion expressed:\u003c\/strong\u003e Cys30-Glu121\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTag:\u003c\/strong\u003e N-His; SUMO; C-Strep\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurification:\u003c\/strong\u003e Affinity-chromatography\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e \u0026gt;90%\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormulation (context):\u003c\/strong\u003e Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eEndotoxin:\u003c\/strong\u003e Not provided in the public listing (contact for details if your assay is endotoxin-sensitive).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eReconstitution:\u003c\/strong\u003e Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003chr\u003e\n\n\u003ch2\u003eResearch interpretation\u003c\/h2\u003e\n\u003cp\u003eIGFBP5 recombinant reagents are most valuable when you need a \u003cstrong\u003edefined molecular input\u003c\/strong\u003e to reduce variability from endogenous expression and processing. For extracellular proteins and viral antigens, folding and glycan\/disulfide status can shift epitope exposure and binding readouts; keeping expression system and construct boundaries consistent improves interpretability.\u003c\/p\u003e","brand":"Biohippo Inc","offers":[{"title":"100 ug","offer_id":53000606744941,"sku":"HC001012-100UG","price":311.0,"currency_code":"USD","in_stock":true},{"title":"1 mg","offer_id":53000606777709,"sku":"HC001012-1MG","price":1627.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/HC001012-SDSPAGE-1.jpg?v=1770274656","url":"https:\/\/www.ebiohippo.com\/products\/recombinant-human-igfbp5-protein-n-his-sumo-and-c-strep-bhp21400021","provider":"BioHippo","version":"1.0","type":"link"}