{"product_id":"recombinant-human-igg2-antibody-biotin-conjugate-bha17103663","title":"Recombinant Human IgG2 Antibody (Biotin Conjugate)","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\n\u003cp\u003e Human IgG2 antibody supplied as a biotin conjugate reagent for ELISA in Human samples. This product is a Recombinant rabbit monoclonal antibody (host: Rabbit; isotype: Rabbit IgG) intended for research use only.\u003c\/p\u003e\n\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\n\u003cul\u003e\n  \u003cli\u003e\n\u003cstrong\u003eAntibody identity:\u003c\/strong\u003e  Rabbit Monoclonal; host Rabbit; isotype Rabbit IgG; clone RM118.\u003c\/li\u003e\n  \u003cli\u003e\n\u003cstrong\u003eFormat and purification:\u003c\/strong\u003e format: Biotin Conjugate; purity: Protein A purified from animal origin-free supernatant.\u003c\/li\u003e\n  \u003cli\u003e\n\u003cstrong\u003eSpecies reactivity (reported):\u003c\/strong\u003e Human.\u003c\/li\u003e\n  \u003cli\u003e\n\u003cstrong\u003eApplications (listed):\u003c\/strong\u003e ELISA.\u003c\/li\u003e\n  \u003cli\u003e\n\u003cstrong\u003eImmunogen \/ epitope context:\u003c\/strong\u003e Human IgG2 was used as the immunogen for this  Human IgG2 antibody..\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eThese attributes help you align the antibody with the biological question (target state, sample type, and readout) while keeping interpretation grounded in appropriate controls.\u003c\/p\u003e\n\u003ch2\u003eBiological background\u003c\/h2\u003e\n\u003cp\u003e Human IgG2 is the intended antigen for this primary antibody. Reported biological context includes: This  Human IgG2 antibody reacts to the heavy chain of human IgG2. No cross reactivity with human IgG1, IgG3, IgG4, IgM, IgA, IgD, IgE, mouse IgG, rat IgG, or goat IgG.\u003c\/p\u003e\n\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\n\u003cul\u003e\n  \u003cli\u003eSpatial and single-cell approaches: imaging-based and cytometry workflows increasingly quantify heterogeneity and relocalization rather than only bulk abundance.\u003c\/li\u003e\n  \u003cli\u003eInteraction-centric biology: IP-based enrichment and proteomics are widely used to define complexes, binding partners, and context-specific interactomes.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eCommon research applications\u003c\/h2\u003e\n\u003cul\u003e\n  \u003cli\u003eELISA: support quantitative detection workflows and assay development where a defined antibody reagent is needed for capture or detection.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eAcross these readouts, differences in signal intensity, localization, or complex enrichment are typically interpreted alongside sample-matched controls and independent evidence to distinguish regulation from technical variation.\u003c\/p\u003e\n\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\n\u003cul\u003e\n  \u003cli\u003eIsoforms, cleavage products, or post-translational modifications can alter apparent molecular weight and subcellular distribution; interpret bands and staining patterns in the context of expected biology and sample preparation.\u003c\/li\u003e\n  \u003cli\u003eSpecies differences and epitope conservation may affect binding; use matched positive controls and orthogonal evidence when comparing across organisms.\u003c\/li\u003e\n  \u003cli\u003eControl concepts: include appropriate isotype and secondary-only controls (for imaging), and consider genetic perturbations (knockout\/knockdown\/overexpression) or independent antibodies targeting distinct epitopes to strengthen conclusions.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eEpitope context is defined by the immunogen description; when available, align this with known domains, PTM sites, or family homology to anticipate potential cross-reactivity patterns. As a monoclonal antibody, binding is driven by a single epitope, which can support consistent recognition but may be sensitive to epitope masking by PTMs or conformational changes.\u003c\/p\u003e\n\u003c!-- Sources (internal):\n- UniProtKB entry (P01859) — UniProt Consortium — https:\/\/www.uniprot.org\/uniprotkb\/P01859\/entry\n- NCBI Gene search ( Human IgG2) — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=+Human+IgG2\n- Ensembl search ( Human IgG2) — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=+Human+IgG2\n- PubMed search ( Human IgG2) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=+Human+IgG2\n- Reactome pathway search ( Human IgG2) — Reactome — https:\/\/reactome.org\/content\/query?q=+Human+IgG2\n--\u003e","brand":"NSJ Bioreagents","offers":[{"title":"1 mg\/ml in PBS with 50% glycerol, 1% BSA and 0.09% sodium azide \/ 50 ug","offer_id":53043674120557,"sku":"R20188BTN-50UG","price":439.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_d107cbff-b60e-46cc-b666-b3b797e6dc11.jpg?v=1771934397","url":"https:\/\/www.ebiohippo.com\/products\/recombinant-human-igg2-antibody-biotin-conjugate-bha17103663","provider":"BioHippo","version":"1.0","type":"link"}