{"product_id":"recombinant-human-il-22bp-il22ra2-protein-his-and-fc-tag-bhp10300724","title":"Recombinant Human IL-22BP\/IL22RA2 Protein (His \u0026 Fc Tag)","description":"\u003cdiv class=\"bhp-desc\"\u003e\n\u003cstyle\u003e.bhp-desc{font-size:16px;color:#1a1a1a;line-height:1.7}.bhp-desc h2{font-size:18px;font-weight:700;color:#003366;margin:24px 0 10px;padding-bottom:6px;border-bottom:2px solid #003366}.bhp-desc p{margin:0 0 12px}.bhp-desc .bhp-spec-table{width:100%;border-collapse:collapse;margin:12px 0 18px}.bhp-desc .bhp-spec-table th{width:36%;text-align:left;padding:8px 12px;background:#e8f0fb;color:#003366;font-weight:600;vertical-align:top;border:1px solid #ccd9f0}.bhp-desc .bhp-spec-table td{padding:8px 12px;vertical-align:top;border:1px solid #ccd9f0}.bhp-desc .bhp-qc-badge{display:inline-block;background:#e6f4ea;color:#1a7a3c;border:1px solid #a8d5b5;border-radius:4px;padding:6px 14px;font-size:14px;font-weight:600}.bhp-desc .bhp-warning-box{background:#fff8e6;border-left:4px solid #e6a817;padding:10px 14px;margin:10px 0 14px;border-radius:0 4px 4px 0}.bhp-desc .bhp-cat-pill{display:inline-block;background:#003366;color:#fff;border-radius:20px;padding:3px 12px;font-size:13px;margin-bottom:10px}\u003c\/style\u003e\n\u003cspan class=\"bhp-cat-pill\"\u003eRecombinant Protein\u003c\/span\u003e\u003ch2\u003eScientific Background\u003c\/h2\u003e\n\u003cp\u003eInterleukin-22 receptor subunit alpha-2 (IL-22RA2); also known as interleukin-22-binding protein (IL-22BP); is a subunit of the receptor for interleukin 22. IL-22BP belongs to the type I I cytokine receptor family and contains 3 fibronectin type-III domains. IL-22BP\/IL-22RA2 is expressed in a range of tissues; including those in the digestive; female reproductive; and immune systems. It is expressed in placenta; spleen; breast; skin and lung. It is also detected in intestinal tract; testis; brain; heart and thymus. The dominant cell types expressing IL-22BP\/IL-22RA2 were mononuclear cells and epithelium. IL-22BP\/IL-22RA2 may play an important role as an IL-22 antagonist in the regulation of inflammatory responses. Interleukin-22 (IL-22) is a member of IL-10 family. It is produced by T cells and induces the production of acute-phase reactants. IL-22 plays important roles in immune response through activation of the STAT 3 signal transduction pathway. Two types of IL-22-binding receptor have been discovered; a membrane-bound receptor and a soluble receptor.\u003c\/p\u003e\n\u003ch2\u003eProduct Description\u003c\/h2\u003e\n\u003cp\u003e\u003cspan class=\"bhp-qc-badge\"\u003eExpression System: HEK293\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eRecombinant human IL-22BP is expressed in HEK293 Cells spanning Met 1-Pro 231, supplied with a C-His-Fc tag. Purity is 90% as determined by reducing SDS-PAGE and the product is provided as a lyophilized preparation.\u003c\/p\u003e\n\u003ch2\u003eProtein Specifications\u003c\/h2\u003e\n\u003ctable class=\"bhp-spec-table\"\u003e\n\u003ctr\u003e\n\u003cth\u003eExpression Host\u003c\/th\u003e\n\u003ctd\u003eHEK293 Cells\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eTag\u003c\/th\u003e\n\u003ctd\u003eC-His-Fc\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eExpression Region\u003c\/th\u003e\n\u003ctd\u003eMet 1-Pro 231\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eCalculated MW\u003c\/th\u003e\n\u003ctd\u003e52.8 kDa\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eObserved MW\u003c\/th\u003e\n\u003ctd\u003e80-90 kDa\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003ePurity\u003c\/th\u003e\n\u003ctd\u003e\u0026gt; 90% as determined by reducing SDS-PAGE.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eEndotoxin Level\u003c\/th\u003e\n\u003ctd\u003e\u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eFormulation\u003c\/th\u003e\n\u003ctd\u003eLyophilized from sterile PBS, pH 7.4\u003cbr\u003eNormally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.\u003cbr\u003ePlease refer to the specific buffer information in the printed manual.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eReconstitution\u003c\/th\u003e\n\u003ctd\u003ePlease refer to the printed manual for detailed information.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eShipping\u003c\/th\u003e\n\u003ctd\u003eThis product is provided as lyophilized powder which is shipped with ice packs.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eStorage\u003c\/th\u003e\n\u003ctd\u003eGenerally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eLead Time\u003c\/th\u003e\n\u003ctd\u003e2-3 business days\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eShelf Life\u003c\/th\u003e\n\u003ctd\u003e12 months\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eAccession Number\u003c\/th\u003e\n\u003ctd\u003eNP_851826.1\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eUniProt #\u003c\/th\u003e\n\u003ctd\u003eQ969J5\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eAlternative Names\u003c\/th\u003e\n\u003ctd\u003eUNQ;Il22ra;IL22RA2;UNQ5793;PRO19598;PRO19822;Class II cytokine receptor;CRF2 10;CRF2 S1;CRF2-10;CRF2-S1;CRF2X;Cytokine receptor class II member 10;Cytokine receptor class-II member 10;Cytokine receptor family 2 member 10;Cytokine receptor family type 2;Cytokine receptor family type 2 soluble 1;I22R2;IL 22 receptor subunit alpha 2;IL 22BP;IL 22R alpha 2;IL 22RA2;IL-22 receptor subunit alpha-2;IL22BP;IL-22BP;IL22R alpha 2;IL-22RA2;IL-22R-alpha-2;Interleukin 22 binding protein;Interleukin 22 Receptor alpha 2;Interleukin-22 receptor subunit alpha-2;Interleukin-22-binding protein;MGC150509;MGC150510;soluble 1;ZcytoR16\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/table\u003e\n\u003ch2\u003eFunctional Activity\u003c\/h2\u003e\n\u003cp\u003eThis lot is supplied as a protein reagent without a validated bioactivity specification. It is suitable for binding assays, immunization, and assay development where enzymatic or receptor activity is not required.\u003c\/p\u003e\n\u003ch2\u003eSafety \u0026amp; Handling\u003c\/h2\u003e\n\u003cdiv class=\"bhp-warning-box\"\u003e\u003cp\u003eThis product is for research use only (RUO) and is not intended for human or veterinary diagnostic or therapeutic use. Handle using standard laboratory safety practices.\u003c\/p\u003e\u003c\/div\u003e\n\u003ch2\u003eRelated Products\u003c\/h2\u003e\n\u003cp\u003eExplore additional recombinant proteins and matched antibodies or ELISA kits for IL-22BP research from Elabscience Biotechnology Co Ltd, or contact us for alternative tags and expression formats.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Elabscience Biotechnology Co Ltd","offers":[{"title":"50 ug","offer_id":53752731468141,"sku":"PKSH031301_50μg","price":701.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/R8804K.jpg?v=1787066133","url":"https:\/\/www.ebiohippo.com\/products\/recombinant-human-il-22bp-il22ra2-protein-his-and-fc-tag-bhp10300724","provider":"BioHippo","version":"1.0","type":"link"}