{"product_id":"recombinant-human-inducible-t-cell-costimulator-bhp11005620","title":"Recombinant Human Inducible T Cell Costimulator","description":"\u003cp\u003e\u003cstrong\u003eRecombinant Human Inducible T Cell Costimulator\u003c\/strong\u003e is supplied as a recombinant protein for in vitro research use.\u003c\/p\u003e\n\u003ch3\u003eBackground\u003c\/h3\u003e\n\u003cp\u003eICOS (inducible T-cell costimulatory) belongs to the CD28 family of immune-assisted stimulatory receptors. ICOS forms homodimers and takes a significant part in immune responses, cell-cell signaling, as well as regulation of cell proliferation. The interaction of B7-H2 \/ ICOS takes a vital role in T-cell differentiation, T-B cell interaction in addition to humoral immune response is essential for the formation of reproductive centers as well as the production of cytokine IL-4. Moreover, ICOS is more effective in inducing IL-10 production, a cytokine which is important for the inhibitory function of T regulatory cells. The ICOS-B7RP-1 and B7-1 \/ B7-2-CD28 \/ CTLA-4 pathways offer a significant second signal which can regulate the inhibition, activation and fine regulation of T-lymphocyte responses. ICOS stimulates the production of Th1 and Th2 cytokines, however it can also participate in the generation of Th2 cells.\u003c\/p\u003e\n\u003ch3\u003eProduct format\u003c\/h3\u003e\n\u003cp\u003eProvided as a recombinant protein suitable for in vitro workflows such as binding studies, screening, and assay development. Refer to the specifications table for expression format and molecular properties.\u003c\/p\u003e","brand":"ProSpec-Tany TechnoGene Ltd","offers":[{"title":"1 ug","offer_id":53038170603885,"sku":"pro-2534-1UG","price":60.0,"currency_code":"USD","in_stock":true},{"title":"5 ug","offer_id":53038519583085,"sku":"pro-2534-5UG","price":145.0,"currency_code":"USD","in_stock":true},{"title":"50 ug","offer_id":53038519615853,"sku":"pro-2534-50UG","price":1200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/Prospecbio-icos-human-PRO-2534.png?v=1782158372","url":"https:\/\/www.ebiohippo.com\/products\/recombinant-human-inducible-t-cell-costimulator-bhp11005620","provider":"BioHippo","version":"1.0","type":"link"}