{"product_id":"recombinant-human-interleukin-1-receptor-like-1-il1rl1-partial-active-bhp10516731","title":"Recombinant Human Interleukin-1 receptor-like 1 (IL1RL1), partial (Active)","description":"\u003ch2\u003eOverview\u003c\/h2\u003e \u003cp\u003eThis product is a recombinant human IL1RL1 protein commonly used as a defined reagent for assay development, interaction studies, and cell-based functional experiments. \u003c\/p\u003e \u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e \u003cul\u003e \u003cli\u003e\n\u003cstrong\u003eExpression region:\u003c\/strong\u003e 19-323aa — region selection can affect binding epitopes and functional interpretation.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eExpression system:\u003c\/strong\u003e Mammalian cell — expression context can influence folding and post-translational features.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eConjugate\/format:\u003c\/strong\u003e C-terminal 10xHis-tagged — useful for platform-specific capture or detection workflows.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eFormat note:\u003c\/strong\u003e Labeled as active in the product title; confirm compatibility with your assay design.\u003c\/li\u003e \u003c\/ul\u003e \u003ch2\u003eBiological background\u003c\/h2\u003e \u003cp\u003eReceptor for interleukin-33 (IL-33) which plays crucial roles in innate and adaptive immunity, contributing to tissue homeostasis and responses to environmental stresses together with coreceptor IL1RAP. Its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3\/ERK1 and\/or MAPK1\/ERK2, MAPK14, and MAPK8.\u003c\/p\u003e \u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e \u003cul\u003e \u003cli\u003eLigand–receptor interactome mapping using biophysical kinetics and orthogonal assays.\u003c\/li\u003e \u003cli\u003eStructure-guided studies of receptor domains, binding interfaces, and regulatory motifs.\u003c\/li\u003e \u003cli\u003ePathway modulation studies comparing receptor engagement across cell types and conditions.\u003c\/li\u003e \u003c\/ul\u003e \u003ch2\u003eCommon research applications\u003c\/h2\u003e \u003cul\u003e \u003cli\u003eUse as a reagent for consistent dosing across in vitro assays\u003c\/li\u003e \u003cli\u003eGenerate standard curves or spike-in controls in buffer or sample matrix for plate assays\u003c\/li\u003e \u003cli\u003eStimulate cultured cells with IL1RL1 (dose–response\/time-course) and track pathway markers\u003c\/li\u003e \u003c\/ul\u003e \u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e \u003cul\u003e \u003cli\u003eConsider isoforms, processing, or post-translational modifications that may differ from endogenous protein across systems.\u003c\/li\u003e \u003cli\u003eFor tagged or labeled formats, confirm that the tag does not occlude binding sites relevant to your readout.\u003c\/li\u003e \u003cli\u003eUse appropriate negative\/positive controls and orthogonal assays when interpreting binding or activity differences.\u003c\/li\u003e \u003c\/ul\u003e \u003c!-- Sources (internal): - UniProt Knowledgebase (UniProt): https:\/\/www.uniprot.org\/ - NCBI Gene (NIH\/NCBI): https:\/\/www.ncbi.nlm.nih.gov\/gene\/ - NCBI Protein (NIH\/NCBI): https:\/\/www.ncbi.nlm.nih.gov\/protein\/ - Reactome Pathway Database: https:\/\/reactome.org\/ - KEGG Pathway Database: https:\/\/www.kegg.jp\/ --\u003e","brand":"CUSABIO TECHNOLOGY LLC","offers":[{"title":"1 mg","offer_id":53059849716077,"sku":"CSB-MP011626HU-1MG","price":1548.0,"currency_code":"USD","in_stock":true},{"title":"100 ug","offer_id":53059905356141,"sku":"CSB-MP011626HU-100UG","price":254.0,"currency_code":"USD","in_stock":true},{"title":"20 ug","offer_id":53059905388909,"sku":"CSB-MP011626HU-20UG","price":102.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/CSB-MP011626HU-SDS.jpg?v=1772294623","url":"https:\/\/www.ebiohippo.com\/products\/recombinant-human-interleukin-1-receptor-like-1-il1rl1-partial-active-bhp10516731","provider":"BioHippo","version":"1.0","type":"link"}