{"product_id":"recombinant-human-interleukin-17-a-f-heterodimer-bhp11000646","title":"Recombinant Human Interleukin-17 A\/F Heterodimer","description":"\u003cp\u003e\u003cstrong\u003eRecombinant Human Interleukin-17 A\/F Heterodimer\u003c\/strong\u003e is supplied as a recombinant protein for in vitro research use.\u003c\/p\u003e\n\u003ch3\u003eBackground\u003c\/h3\u003e\n\u003cp\u003eHuman IL-17A\/F is a 40kDa glycoprotein which is secreted as a disulfide-linked heterodimer. IL-17A\/F consists of two proteins of the IL-17 family, IL-17A and IL17F. Proteins of the 6 homodimeric IL17 family show a cysteine knot motif that contains two disulfide-bonds. Human IL17A is produced as a 155 a.a precursor that includes a 23 amino acids signal sequence and a 132 amino acid chain that includes an N-linked glycosylation site. Human IL17F is produced as a 153 amino acid precursor with a 20 amino acid signal sequence and a 133 amino acid region. Similar to IL17A, IL17F also has an N-linked glycosylation site. Both proteins (IL17A \u0026amp; IL17F) share 50% amino acid sequence identity. Human IL17A \u0026amp; IL17F show approximately 60% homology in their amino acid sequence to mouse IL-17A and IL-17F. Interleukin-17A\/F and IL17A, IL17F homodimers are manufactured by activted CD4+ T cells, called Th17. IL-23 causes Th17 lymphocytes to manufacture IL-17A\/F. IL17RA and IL17RC form a heterodimer for the binding of IL17A and IL17F. IL-17A\/F binds IL-17RA. Interleukin-17A\/F induces chemokine production and airway neutrophilia with intermediate potency between IL17A (most potent) and IL17F (least potent).\u003c\/p\u003e\n\u003ch3\u003eProduct format\u003c\/h3\u003e\n\u003cp\u003eProvided as a recombinant protein suitable for in vitro workflows such as binding studies, screening, and assay development. Refer to the specifications table for expression format and molecular properties.\u003c\/p\u003e","brand":"ProSpec-Tany TechnoGene Ltd","offers":[{"title":"2 ug","offer_id":53038058340717,"sku":"cyt-623-2UG","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10 ug","offer_id":53038298333549,"sku":"cyt-623-10UG","price":145.0,"currency_code":"USD","in_stock":true},{"title":"100 ug","offer_id":53038298366317,"sku":"cyt-623-100UG","price":900.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/Prospecbio-il-17-a-f-human-CYT-623.png?v=1782158145","url":"https:\/\/www.ebiohippo.com\/products\/recombinant-human-interleukin-17-a-f-heterodimer-bhp11000646","provider":"BioHippo","version":"1.0","type":"link"}