{"product_id":"recombinant-human-keratin-type-i-cytoskeletal-19-krt19-bhp10506972","title":"Recombinant Human Keratin, type I cytoskeletal 19 (KRT19)","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eThis Recombinant Protein provides recombinant \u003cstrong\u003eKRT19\u003c\/strong\u003e from Homo sapiens (Human), produced in Baculovirus (region 1-400aa). It is commonly used as a defined reagent for assay development, binding studies, and mechanistic research (RUO).\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eRegion:\u003c\/strong\u003e 1-400aa (domain boundaries can affect binding\/activity readouts).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eExpression host:\u003c\/strong\u003e Baculovirus (may differ from native PTMs\/processing).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTag(s):\u003c\/strong\u003e His, Myc (supports purification\/detection; consider tag effects in controls).\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cp\u003eAlso reported as Cytokeratin-19 (CK-19) (Keratin-19) (K19). Involved in the organization of myofibers. Together with KRT8, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.\u003c\/p\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\u003cli\u003eUse of recombinant standards to improve assay calibration and cross-study comparability.\u003c\/li\u003e\u003c\/ul\u003e\u003cp\u003eInvolved in the organization of myofibers. Together with KRT8, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.\u003c\/p\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eStandard curve or spike-in reference for quantitative assays involving KRT19\u003c\/li\u003e\n\u003cli\u003eBinding and specificity benchmarking for detection reagents (conceptual)\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eRecombinant constructs may not capture all native isoforms or PTMs.\u003c\/li\u003e\n\u003cli\u003eConsider tag- or host-related effects when interpreting binding or activity.\u003c\/li\u003e\n\u003cli\u003eUse appropriate blanks and matrix\/control concepts to separate signal from background.\u003c\/li\u003e\n\u003c\/ul\u003e\u003c!-- Sources (internal): - UniProtKB P08727 — UniProt — https:\/\/www.uniprot.org\/uniprotkb\/P08727 - NCBI Gene search: KRT19 — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=KRT19 - Ensembl search: KRT19 — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=KRT19 - Reactome Pathway Browser — Reactome — https:\/\/reactome.org\/ - NCBI Bookshelf — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/books\/ --\u003e","brand":"CUSABIO TECHNOLOGY LLC","offers":[{"title":"1 mg","offer_id":53053399204205,"sku":"CSB-BP012534HU-1MG","price":2710.0,"currency_code":"USD","in_stock":true},{"title":"100 ug","offer_id":53053518381421,"sku":"CSB-BP012534HU-100UG","price":1120.0,"currency_code":"USD","in_stock":true},{"title":"20 ug","offer_id":53053518414189,"sku":"CSB-BP012534HU-20UG","price":400.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/CSB-BP012534HU-SDS.jpg?v=1772177620","url":"https:\/\/www.ebiohippo.com\/products\/recombinant-human-keratin-type-i-cytoskeletal-19-krt19-bhp10506972","provider":"BioHippo","version":"1.0","type":"link"}