{"product_id":"recombinant-human-leucine-rich-repeat-containing-g-protein-coupled-receptor-5-lgr5-partial-bhp10516769","title":"Recombinant Human Leucine-rich repeat-containing G-protein coupled receptor 5 (LGR5) , partial","description":"\u003ch2\u003eOverview\u003c\/h2\u003e \u003cp\u003eThis product is a recombinant human LGR5 protein commonly used as a defined reagent for assay development, interaction studies, and cell-based functional experiments. \u003c\/p\u003e \u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e \u003cul\u003e \u003cli\u003e\n\u003cstrong\u003eExpression region:\u003c\/strong\u003e 22-561aa — region selection can affect binding epitopes and functional interpretation.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eExpression system:\u003c\/strong\u003e Mammalian cell — expression context can influence folding and post-translational features.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eConjugate\/format:\u003c\/strong\u003e C-terminal 10xHis-tagged — useful for platform-specific capture or detection workflows.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eFormat note:\u003c\/strong\u003e Labeled as partial in the product title; confirm compatibility with your assay design.\u003c\/li\u003e \u003c\/ul\u003e \u003ch2\u003eBiological background\u003c\/h2\u003e \u003cp\u003eReceptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes.\u003c\/p\u003e \u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e \u003cul\u003e \u003cli\u003eLigand–receptor interactome mapping using biophysical kinetics and orthogonal assays.\u003c\/li\u003e \u003cli\u003eStructure-guided studies of receptor domains, binding interfaces, and regulatory motifs.\u003c\/li\u003e \u003cli\u003ePathway modulation studies comparing receptor engagement across cell types and conditions.\u003c\/li\u003e \u003c\/ul\u003e \u003ch2\u003eCommon research applications\u003c\/h2\u003e \u003cul\u003e \u003cli\u003eUse as a reagent for consistent dosing across in vitro assays\u003c\/li\u003e \u003cli\u003eGenerate standard curves or spike-in controls in buffer or sample matrix for plate assays\u003c\/li\u003e \u003cli\u003eProfile protein–protein interactions involving LGR5 using pull-down or co-binding assays\u003c\/li\u003e \u003c\/ul\u003e \u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e \u003cul\u003e \u003cli\u003eConsider isoforms, processing, or post-translational modifications that may differ from endogenous protein across systems.\u003c\/li\u003e \u003cli\u003eFor tagged or labeled formats, confirm that the tag does not occlude binding sites relevant to your readout.\u003c\/li\u003e \u003cli\u003eUse appropriate negative\/positive controls and orthogonal assays when interpreting binding or activity differences.\u003c\/li\u003e \u003c\/ul\u003e \u003c!-- Sources (internal): - UniProt Knowledgebase (UniProt): https:\/\/www.uniprot.org\/ - NCBI Gene (NIH\/NCBI): https:\/\/www.ncbi.nlm.nih.gov\/gene\/ - NCBI Protein (NIH\/NCBI): https:\/\/www.ncbi.nlm.nih.gov\/protein\/ - Reactome Pathway Database: https:\/\/reactome.org\/ - KEGG Pathway Database: https:\/\/www.kegg.jp\/ --\u003e","brand":"CUSABIO TECHNOLOGY LLC","offers":[{"title":"1 mg","offer_id":53059847618925,"sku":"CSB-MP012906HUd7-1MG","price":2490.0,"currency_code":"USD","in_stock":true},{"title":"100 ug","offer_id":53059906142573,"sku":"CSB-MP012906HUd7-100UG","price":344.0,"currency_code":"USD","in_stock":true},{"title":"20 ug","offer_id":53059906175341,"sku":"CSB-MP012906HUd7-20UG","price":138.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/CSB-MP012906HUd7-SDS.jpg?v=1772294658","url":"https:\/\/www.ebiohippo.com\/products\/recombinant-human-leucine-rich-repeat-containing-g-protein-coupled-receptor-5-lgr5-partial-bhp10516769","provider":"BioHippo","version":"1.0","type":"link"}