{"product_id":"recombinant-human-methylmalonic-aciduria-cblc-type-with-homocystinuria-bhp11003697","title":"Recombinant Human Methylmalonic Aciduria cblC type, with Homocystinuria","description":"\u003cp\u003e\u003cstrong\u003eRecombinant Human Methylmalonic Aciduria cblC type, with Homocystinuria\u003c\/strong\u003e is supplied as a recombinant protein for in vitro research use.\u003c\/p\u003e\n\u003ch3\u003eBackground\u003c\/h3\u003e\n\u003cp\u003eThough the exact role of MMACHC is unknown, its C-terminal region shows similarity to TonB, which is a bacterial protein involved in energy transduction for cobalamin (vitamin B12) uptake. Therefore, it is suggested that MMACHC may have a role in the binding and intracellular trafficking of cobalamin. MMACHC mutations are linked with methylmalonic aciduria and homocystinuria type cblC. MMACHC is widely expressed, it is expressed at higher level in the fetal liver, however it is also expressed in the spleen, lymph node, thymus and bone marrow. MMACHC is weakly or not expressed in the peripheral blood leukocytes.\u003c\/p\u003e\n\u003ch3\u003eProduct format\u003c\/h3\u003e\n\u003cp\u003eProvided as a recombinant protein suitable for in vitro workflows such as binding studies, screening, and assay development. Refer to the specifications table for expression format and molecular properties.\u003c\/p\u003e","brand":"ProSpec-Tany TechnoGene Ltd","offers":[{"title":"5 ug","offer_id":53038121320813,"sku":"pro-1119-5UG","price":60.0,"currency_code":"USD","in_stock":true},{"title":"20 ug","offer_id":53038423474541,"sku":"pro-1119-20UG","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1 mg","offer_id":53038423507309,"sku":"pro-1119-1MG","price":2700.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/Prospecbio-mmachc-human-PRO-1119.png?v=1782158278","url":"https:\/\/www.ebiohippo.com\/products\/recombinant-human-methylmalonic-aciduria-cblc-type-with-homocystinuria-bhp11003697","provider":"BioHippo","version":"1.0","type":"link"}