{"product_id":"recombinant-human-mhc-class-i-polypeptide-related-sequence-b-micb-partial-active-bhp10516778","title":"Recombinant Human MHC class I polypeptide-related sequence B (MICB), partial (Active)","description":"\u003ch2\u003eOverview\u003c\/h2\u003e \u003cp\u003eThis product is a recombinant human MICB protein commonly used as a defined reagent for assay development, interaction studies, and cell-based functional experiments. \u003c\/p\u003e \u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e \u003cul\u003e \u003cli\u003e\n\u003cstrong\u003eExpression region:\u003c\/strong\u003e 23-309aa — region selection can affect binding epitopes and functional interpretation.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eExpression system:\u003c\/strong\u003e Mammalian cell — expression context can influence folding and post-translational features.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eConjugate\/format:\u003c\/strong\u003e C-terminal 10xHis-tagged — useful for platform-specific capture or detection workflows.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eFormat note:\u003c\/strong\u003e Labeled as active in the product title; confirm compatibility with your assay design.\u003c\/li\u003e \u003c\/ul\u003e \u003ch2\u003eBiological background\u003c\/h2\u003e \u003cp\u003eWidely expressed membrane-bound protein which acts as a ligand to stimulate an activating receptor KLRK1\/NKG2D, expressed on the surface of essentially all human natural killer (NK), gammadelta T and CD8+ alphabeta T-cells. Up-regulated in stressed conditions, such as viral and bacterial infections or DNA damage response, serves as signal of cellular stress, and engagement of KLRK1\/NKG2D by MICA triggers NK-cells resulting in a range of immune effector functions, such as cytotoxicity and cytokine production.\u003c\/p\u003e \u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e \u003cul\u003e \u003cli\u003eAssay development that combines purified proteins with cell-based readouts for cross-validation.\u003c\/li\u003e \u003cli\u003eDomain- and isoform-aware studies to interpret binding specificity and functional outcomes.\u003c\/li\u003e \u003cli\u003eIntegration of recombinant proteins into multi-omics workflows for pathway characterization.\u003c\/li\u003e \u003c\/ul\u003e \u003ch2\u003eCommon research applications\u003c\/h2\u003e \u003cul\u003e \u003cli\u003eUse as a reagent for consistent dosing across in vitro assays\u003c\/li\u003e \u003cli\u003eGenerate standard curves or spike-in controls in buffer or sample matrix for plate assays\u003c\/li\u003e \u003cli\u003eProfile protein–protein interactions involving MICB using pull-down or co-binding assays\u003c\/li\u003e \u003c\/ul\u003e \u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e \u003cul\u003e \u003cli\u003eConsider isoforms, processing, or post-translational modifications that may differ from endogenous protein across systems.\u003c\/li\u003e \u003cli\u003eFor tagged or labeled formats, confirm that the tag does not occlude binding sites relevant to your readout.\u003c\/li\u003e \u003cli\u003eUse appropriate negative\/positive controls and orthogonal assays when interpreting binding or activity differences.\u003c\/li\u003e \u003c\/ul\u003e \u003c!-- Sources (internal): - UniProt Knowledgebase (UniProt): https:\/\/www.uniprot.org\/ - NCBI Gene (NIH\/NCBI): https:\/\/www.ncbi.nlm.nih.gov\/gene\/ - NCBI Protein (NIH\/NCBI): https:\/\/www.ncbi.nlm.nih.gov\/protein\/ - Reactome Pathway Database: https:\/\/reactome.org\/ - KEGG Pathway Database: https:\/\/www.kegg.jp\/ --\u003e","brand":"CUSABIO TECHNOLOGY LLC","offers":[{"title":"1 mg","offer_id":53059847356781,"sku":"CSB-MP013813HUd7-1MG","price":2490.0,"currency_code":"USD","in_stock":true},{"title":"100 ug","offer_id":53059907486061,"sku":"CSB-MP013813HUd7-100UG","price":312.0,"currency_code":"USD","in_stock":true},{"title":"20 ug","offer_id":53059907518829,"sku":"CSB-MP013813HUd7-20UG","price":126.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/CSB-MP013813HUd7-SDS.jpg?v=1772294585","url":"https:\/\/www.ebiohippo.com\/products\/recombinant-human-mhc-class-i-polypeptide-related-sequence-b-micb-partial-active-bhp10516778","provider":"BioHippo","version":"1.0","type":"link"}