{"product_id":"recombinant-human-mitogen-activated-protein-kinase-1-active-bhp11001337","title":"Recombinant Human Mitogen-Activated Protein Kinase 1, Active","description":"\u003cp\u003e\u003cstrong\u003eRecombinant Human Mitogen-Activated Protein Kinase 1, Active\u003c\/strong\u003e is supplied as a recombinant protein for in vitro research use.\u003c\/p\u003e\n\u003ch3\u003eBackground\u003c\/h3\u003e\n\u003cp\u003eMitogen-activated protein kinase 1 (MAPK1) is also known as \"extracellular signal-regulated kinase 2\" (ERK2). Two similar (85% sequence identity) protein kinases were originally called ERK1 and ERK2. They were found during a search for protein kinases that are rapidly phosphorylated after activation of cell surface tyrosine kinasessuch as the epidermal growth factor receptor. Phosphorylation of ERKs leads to the activation of their kinase activity. The molecular events linking cell surface receptors to activation of ERKs are complex. It was found that RasGTP-binding proteins are involved in the activation of ERKs. Another protein kinase, Raf-1, was shown to phosphorylate a \"MAPK kinase\", thus qualifying as a \"MAPK kinase kinase\". The MAPK kinase was named \"MAPK\/ERK kinase\" (MEK). Receptor-linked tyrosine kinases, Ras, Raf, MEK and MAPK could be fitted into a signaling cascade linking an extracellular signal to MAPK activation. Transgenic gene knockoutmice lacking MAPK1 have major defects in early development.\u003c\/p\u003e\n\u003ch3\u003eProduct format\u003c\/h3\u003e\n\u003cp\u003eProvided as a recombinant protein suitable for in vitro workflows such as binding studies, screening, and assay development. Refer to the specifications table for expression format and molecular properties.\u003c\/p\u003e\n\u003ch3\u003eActivity \u0026amp; assay information\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eSpecific Activity:\u003c\/strong\u003e 386 pmol\/µgxmin ATP-K M : 1.7µM\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"ProSpec-Tany TechnoGene Ltd","offers":[{"title":"1 ug","offer_id":53038067777901,"sku":"pka-214-1UG","price":60.0,"currency_code":"USD","in_stock":true},{"title":"5 ug","offer_id":53038317830509,"sku":"pka-214-5UG","price":145.0,"currency_code":"USD","in_stock":true},{"title":"100 ug","offer_id":53038317863277,"sku":"pka-214-100UG","price":2000.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/Prospecbio-mapk1-human-active-PKA-214.png?v=1782158164","url":"https:\/\/www.ebiohippo.com\/products\/recombinant-human-mitogen-activated-protein-kinase-1-active-bhp11001337","provider":"BioHippo","version":"1.0","type":"link"}