{"product_id":"recombinant-human-mitogen-activated-protein-kinase-1-his-tag-bhp11001340","title":"Recombinant Human Mitogen-Activated Protein Kinase 1 His Tag","description":"\u003cp\u003e\u003cstrong\u003eRecombinant Human Mitogen-Activated Protein Kinase 1 His Tag\u003c\/strong\u003e is supplied as a recombinant protein for in vitro research use.\u003c\/p\u003e\n\u003ch3\u003eBackground\u003c\/h3\u003e\n\u003cp\u003eMitogen-activated protein kinase 1 (MAPK1) is also known as \"extracellular signal-regulated kinase 2\" (ERK2). Two similar (85% sequence identity) protein kinases were originally called ERK1 and ERK2. They were found during a search for protein kinases that are rapidly phosphorylated after activation of cell surface tyrosine kinases such as the epidermal growth factor receptor. Phosphorylation of ERKs leads to the activation of their kinase activity.The molecular events linking cell surface receptors to activation of ERKs are complex. It was found that Ras GTP-binding proteins are involved in the activation of ERKs. Another protein kinase, Raf-1, was shown to phosphorylate a \"MAPK kinase\", thus qualifying as a \"MAPK kinase kinase\". The MAPK kinase was named \"MAPK\/ERK kinase\" (MEK). Receptor-linked tyrosine kinases, Ras, Raf, MEK and MAPK could be fitted into a signaling cascade linking an extracellular signal to MAPK activation Transgenic gene knockout mice lacking MAPK1 have major defe\u003c\/p\u003e\n\u003ch3\u003eProduct format\u003c\/h3\u003e\n\u003cp\u003eProvided as a recombinant protein suitable for in vitro workflows such as binding studies, screening, and assay development. Refer to the specifications table for expression format and molecular properties.\u003c\/p\u003e","brand":"ProSpec-Tany TechnoGene Ltd","offers":[{"title":"5 ug","offer_id":53038067515757,"sku":"pka-360-5UG","price":60.0,"currency_code":"USD","in_stock":true},{"title":"25 ug","offer_id":53038318223725,"sku":"pka-360-25UG","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1 mg","offer_id":53038318256493,"sku":"pka-360-1MG","price":2250.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/Prospecbio-mapk1-human-his-PKA-360.png?v=1782158165","url":"https:\/\/www.ebiohippo.com\/products\/recombinant-human-mitogen-activated-protein-kinase-1-his-tag-bhp11001340","provider":"BioHippo","version":"1.0","type":"link"}