{"product_id":"recombinant-human-mitogen-activated-protein-kinase-activated-protein-kinase-3-bhp11001716","title":"Recombinant Human Mitogen-Activated Protein Kinase-Activated Protein Kinase 3","description":"\u003cp\u003e\u003cstrong\u003eRecombinant Human Mitogen-Activated Protein Kinase-Activated Protein Kinase 3\u003c\/strong\u003e is supplied as a recombinant protein for in vitro research use.\u003c\/p\u003e\n\u003ch3\u003eBackground\u003c\/h3\u003e\n\u003cp\u003eMAP kinase-activated protein kinase 3 (MAPKAPK3) is involved in inflammatory Reaction by regulating tumor necrosis factor (TNF) and IL6 production post-transcriptionally. MAPKAPK3 phosphorylates AU-rich elements (AREs)-binding proteins, like TTP\/ZFP36, leading to control of stability and translation of TNF and IL6 mRNAs. Phosphorylation of TTP\/ZFP36 (a major post-transcriptional regulator of TNF), promotes its binding to 14-3-3 proteins and reduces its ARE mRNA affinity resulting in inhibition of dependent degradation of ARE-containing transcript. MAPKAPK3 is activated by growth inducers and stress stimulation of cells.\u003c\/p\u003e\n\u003ch3\u003eProduct format\u003c\/h3\u003e\n\u003cp\u003eProvided as a recombinant protein suitable for in vitro workflows such as binding studies, screening, and assay development. Refer to the specifications table for expression format and molecular properties.\u003c\/p\u003e","brand":"ProSpec-Tany TechnoGene Ltd","offers":[{"title":"5 ug","offer_id":53038069907821,"sku":"pka-045-5UG","price":60.0,"currency_code":"USD","in_stock":true},{"title":"20 ug","offer_id":53038320648557,"sku":"pka-045-20UG","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1 mg","offer_id":53038320681325,"sku":"pka-045-1MG","price":2700.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/Prospecbio-mapkapk3-human-PKA-045.png?v=1782158168","url":"https:\/\/www.ebiohippo.com\/products\/recombinant-human-mitogen-activated-protein-kinase-activated-protein-kinase-3-bhp11001716","provider":"BioHippo","version":"1.0","type":"link"}