{"product_id":"recombinant-human-mitogen-activated-protein-kinase-kinase-2-bhp11001330","title":"Recombinant Human Mitogen-Activated Protein Kinase Kinase 2","description":"\u003cp\u003e\u003cstrong\u003eRecombinant Human Mitogen-Activated Protein Kinase Kinase 2\u003c\/strong\u003e is supplied as a recombinant protein for in vitro research use.\u003c\/p\u003e\n\u003ch3\u003eBackground\u003c\/h3\u003e\n\u003cp\u003eMitogen-Activated Protein Kinase Kinase 2 (MAP2K2) is a dual specificity protein kinase, which is a member of the STE grouping of kinases and the MAP kinase kinase family. MAP2K2 is activated by a wide range of growth factors and cytokines and also by membrane depolarization and calcium influx. The MAP2K2 kinase is known for its vital role in mitogen growth factor signal transduction. MAP2K2 phosphorylates and consequently activates MAPK1\/ERK2 and MAPK2\/ERK3. The activation of the MAP2K2 kinase itself is dependent on the Ser\/Thr phosphorylation by MAP kinase kinase kinases. The inhibition or degradation of the MAP2K2 kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. MAP2K2 gene mutations cause cardiofaciocutaneous syndrome (CFC syndrome).\u003c\/p\u003e\n\u003ch3\u003eProduct format\u003c\/h3\u003e\n\u003cp\u003eProvided as a recombinant protein suitable for in vitro workflows such as binding studies, screening, and assay development. Refer to the specifications table for expression format and molecular properties.\u003c\/p\u003e","brand":"ProSpec-Tany TechnoGene Ltd","offers":[{"title":"1 ug","offer_id":53038066893165,"sku":"pka-029-1UG","price":60.0,"currency_code":"USD","in_stock":true},{"title":"5 ug","offer_id":53038317240685,"sku":"pka-029-5UG","price":145.0,"currency_code":"USD","in_stock":true},{"title":"50 ug","offer_id":53038317273453,"sku":"pka-029-50UG","price":1200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/Prospecbio-map2k2-human-PKA-029.png?v=1782158164","url":"https:\/\/www.ebiohippo.com\/products\/recombinant-human-mitogen-activated-protein-kinase-kinase-2-bhp11001330","provider":"BioHippo","version":"1.0","type":"link"}