{"product_id":"recombinant-human-mothers-against-decapentaplegic-homolog-3-bhp11004891","title":"Recombinant Human Mothers Against Decapentaplegic Homolog 3","description":"\u003cp\u003e\u003cstrong\u003eRecombinant Human Mothers Against Decapentaplegic Homolog 3\u003c\/strong\u003e is supplied as a recombinant protein for in vitro research use.\u003c\/p\u003e\n\u003ch3\u003eBackground\u003c\/h3\u003e\n\u003cp\u003eSMAD3 is part of the SMAD family of proteins that mediate signal transduction by the TGF-beta\/activin\/BMP-2\/4 cytokine superfamily from receptor Ser\/Thr protein kinases at the cell surface to the nucleus. SMAD3 has a role as a transcriptional modulator activated by TGF-Beta and is involved in the regulation of carcinogenesis. SMAD3 mutations are related with the pathogenesis of human osteoarthritis. SMAD3 expression take part in tumor suppression in the premature stages of gastric carcinogenesis. SMAD3 is involved in nuclear translocation of beta-catenin.\u003c\/p\u003e\n\u003ch3\u003eProduct format\u003c\/h3\u003e\n\u003cp\u003eProvided as a recombinant protein suitable for in vitro workflows such as binding studies, screening, and assay development. Refer to the specifications table for expression format and molecular properties.\u003c\/p\u003e","brand":"ProSpec-Tany TechnoGene Ltd","offers":[{"title":"5 ug","offer_id":53038162018669,"sku":"pro-751-5UG","price":60.0,"currency_code":"USD","in_stock":true},{"title":"25 ug","offer_id":53038500708717,"sku":"pro-751-25UG","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1 mg","offer_id":53038500741485,"sku":"pro-751-1MG","price":2250.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/Prospecbio-smad3-human-PRO-751.png?v=1782158354","url":"https:\/\/www.ebiohippo.com\/products\/recombinant-human-mothers-against-decapentaplegic-homolog-3-bhp11004891","provider":"BioHippo","version":"1.0","type":"link"}