{"product_id":"recombinant-human-p38-alpha-sapk2-alpha-bhp11001744","title":"Recombinant Human p38 alpha\/SAPK2 alpha","description":"\u003cp\u003e\u003cstrong\u003eRecombinant Human p38 alpha\/SAPK2 alpha\u003c\/strong\u003e is supplied as a recombinant protein for in vitro research use.\u003c\/p\u003e\n\u003ch3\u003eBackground\u003c\/h3\u003e\n\u003cp\u003ep38a\/SAPK2 is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1\/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.\u003c\/p\u003e\n\u003ch3\u003eProduct format\u003c\/h3\u003e\n\u003cp\u003eProvided as a recombinant protein suitable for in vitro workflows such as binding studies, screening, and assay development. Refer to the specifications table for expression format and molecular properties.\u003c\/p\u003e\n\u003ch3\u003eActivity \u0026amp; assay information\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eUnit Definition:\u003c\/strong\u003e No protease activity detectable, specific activity is 2.357.900 U*\/mg (*1 U = 1 pmol\/min transferred to myelin basic protein at 30°C).\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"ProSpec-Tany TechnoGene Ltd","offers":[{"title":"1 ug","offer_id":53038069645677,"sku":"pka-217-1UG","price":130.0,"currency_code":"USD","in_stock":true},{"title":"5 ug","offer_id":53038323073389,"sku":"pka-217-5UG","price":440.0,"currency_code":"USD","in_stock":true},{"title":"20 ug","offer_id":53038323106157,"sku":"pka-217-20UG","price":1050.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/Prospecbio-p38alpha-human-PKA-217.png?v=1782158173","url":"https:\/\/www.ebiohippo.com\/products\/recombinant-human-p38-alpha-sapk2-alpha-bhp11001744","provider":"BioHippo","version":"1.0","type":"link"}