{"product_id":"recombinant-human-phosphoinositide-3-kinase-beta-p110-p85a-bhp11001621","title":"Recombinant Human  Phosphoinositide 3-kinase beta P110β\/p85a","description":"\u003cp\u003e\u003cstrong\u003eRecombinant Human  Phosphoinositide 3-kinase beta P110β\/p85a\u003c\/strong\u003e is supplied as a recombinant protein for in vitro research use.\u003c\/p\u003e\n\u003ch3\u003eBackground\u003c\/h3\u003e\n\u003cp\u003eThe PI3Kb isoform can be activated by insulin via the insulin receptor to initiate a cascade of events that control cell growth and metabolism. The activation of PI3Kb is mediated by the p85 regulatory subunit binding to tyrosine phosphorylated insulin receptor substrate (IRS) proteins (e.g. IRS-1 and IRS-2). It was also shown that PI3Kb is involved in apoptosis in human colon carcinoma cells. Injection of neutralizing antibodies specific to p110b in WiDr, HCT116 and CO 115 adenocarcinoma cells inhibited de novo DNA synthesis. PI3Kb is the major PI3K isoform required for apoptotic cell and Fc-g receptor mediated phagocytosis shown for primary mouse macrophages and the Jurkat human leukemia T cell line. It was shown by several research groups that the catalytic subunit of PI3Kb can be activated by Gbg subunits of G-protein coupled receptors.\u003c\/p\u003e\n\u003ch3\u003eProduct format\u003c\/h3\u003e\n\u003cp\u003eProvided as a recombinant protein suitable for in vitro workflows such as binding studies, screening, and assay development. Refer to the specifications table for expression format and molecular properties.\u003c\/p\u003e","brand":"ProSpec-Tany TechnoGene Ltd","offers":[{"title":"1 ug","offer_id":53038068007277,"sku":"pka-333-1UG","price":130.0,"currency_code":"USD","in_stock":true},{"title":"2.5 ug","offer_id":53038318813549,"sku":"pka-333-25UG","price":250.0,"currency_code":"USD","in_stock":true},{"title":"5 ug","offer_id":53038318846317,"sku":"pka-333-5UG","price":450.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/Prospecbio-pi3kb-human-PKA-333.png?v=1782158165","url":"https:\/\/www.ebiohippo.com\/products\/recombinant-human-phosphoinositide-3-kinase-beta-p110-p85a-bhp11001621","provider":"BioHippo","version":"1.0","type":"link"}