{"product_id":"recombinant-human-pigment-epithelium-derived-factor-bhp11002770","title":"Recombinant Human Pigment Epithelium-Derived Factor","description":"\u003cp\u003e\u003cstrong\u003eRecombinant Human Pigment Epithelium-Derived Factor\u003c\/strong\u003e is supplied as a recombinant protein for in vitro research use.\u003c\/p\u003e\n\u003ch3\u003eBackground\u003c\/h3\u003e\n\u003cp\u003ePEDF is a noninhibitory serpin with neurotrophic, anti-angiogenic, and anti-tumorigenic properties. PEDF is a 50,000 dalton glycoprotein created and secreted in many tissues all the way through the body. A key component of the anti-angiogenic action of PEDF is the induction of apoptosis in proliferating endothelial cells. Additionally, PEDF is capable to inhibit the activity of angiogenic factors such as VEGF and FGF-2. The neuro-protective effects of PEDF are achieved through suppression of neuronal apoptosis induced by peroxide, glutamate, or other neurotoxins. The recognition of a lipase-linked cell membrane receptor for PEDF (PEDF-R) that binds to PEDF with high affinity should facilitate further elucidation of the underlying mechanisms of this pluripotent serpin. To date, PEDF-R is the only signaling receptor known to be used by a serpin family member. The unique range of PEDF activities associate it as a potential therapeutic agent for the treatment of vasculature related neurodegenerative diseases such as age-related macular degeneration (AMD) and proliferative diabetic retinopathy (PDR). PEDF in addition has the potential to be functional in the treatment of various angiogenesis-related diseases including a number of cancers.\u003c\/p\u003e\n\u003cp\u003eAbout PEDF Human Also known as “Pigment Epithelium-Derived Factor” or “SERPINF1,” PEDF is a multifunctional protein found in vertebrates. It has anti-tumorigenic, anti-angiogenic, and neurotrophic functions. Currently, it’s being researched as a candidate for treatment for several conditions, including heart disease and cancer. What’s the Function of PEDF Human Recombinant? PEDF is created\/secreted in several tissues across the body. It has a unique anti-angiogenic action because of its induction of apoptosis in proliferating endothelial cells. Also, PEDF can inhibit many angiogenic factors, including VEGF and FGF-2. PEDF-R is currently the only known signaling receptor to be used by a serpin family member. What’s the Application of PEDF Human Recombinant? This version of PEDF is produced in E. Coli. It’s a single, non-glycosylated, polypeptide chain that contains 400 amino acids. It has a molecular mass of 44.5 kDa, and it’s purified by proprietary chromatographic techniques. The main purpose of PEDF human recombinant is for research. It has the potential to become a potential treatment for different angiogenesis-related diseases, including various cancers. Moreover, it can become crucial during the recovery from vasculature- related neurodegenerative illness. Such a discovery could be revolutionary for the world, which is why more research is needed to determine the effect of this non-inhibitory serpin on the body.\u003c\/p\u003e\n\u003ch3\u003eProduct format\u003c\/h3\u003e\n\u003cp\u003eProvided as a recombinant protein suitable for in vitro workflows such as binding studies, screening, and assay development. Refer to the specifications table for expression format and molecular properties.\u003c\/p\u003e","brand":"ProSpec-Tany TechnoGene Ltd","offers":[{"title":"5 ug","offer_id":53038091272557,"sku":"cyt-580-5UG","price":60.0,"currency_code":"USD","in_stock":true},{"title":"20 ug","offer_id":53038364787053,"sku":"cyt-580-20UG","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1 mg","offer_id":53038364819821,"sku":"cyt-580-1MG","price":3510.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/Prospecbio-serpinf1-human-CYT-580.png?v=1782158216","url":"https:\/\/www.ebiohippo.com\/products\/recombinant-human-pigment-epithelium-derived-factor-bhp11002770","provider":"BioHippo","version":"1.0","type":"link"}