{"product_id":"recombinant-human-placenta-growth-factor-protein-pgf-active-bhp10506028","title":"Recombinant Human Placenta growth factor protein (PGF) (Active)","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eThis Recombinant Protein provides recombinant \u003cstrong\u003ePGF\u003c\/strong\u003e from Homo sapiens (Human), produced in E.Coli (region 19-170aa). It is commonly used as a defined reagent for assay development, binding studies, and mechanistic research (RUO).\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eRegion:\u003c\/strong\u003e 19-170aa (domain boundaries can affect binding\/activity readouts).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eExpression host:\u003c\/strong\u003e E.Coli (may differ from native PTMs\/processing).\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cp\u003eAlso reported as PlGF,. Growth factor active in angiogenesis and endothelial cell growth, stimulating their proliferation and migration. It binds to the receptor FLT1\/VEGFR-1. Isoform PlGF-2 binds NRP1\/neuropilin-1 and NRP2\/neuropilin-2 in a heparin-dependent manner. Also promotes cell tumor growth.\u003c\/p\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eQuantitative mapping of ligand\/receptor signaling to downstream phospho- and transcriptional programs.\u003c\/li\u003e\n\u003cli\u003eUse of recombinant standards to improve assay calibration and cross-study comparability.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eGrowth factor active in angiogenesis and endothelial cell growth, stimulating their proliferation and migration. It binds to the receptor FLT1\/VEGFR-1. Isoform PlGF-2 binds NRP1\/neuropilin-1 and NRP2\/neuropilin-2 in a heparin-dependent manner. Also promotes cell tumor growth. {ECO:0000269|PubMed:21215706}.\u003c\/p\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eStandard curve or spike-in reference for quantitative assays involving PGF\u003c\/li\u003e\n\u003cli\u003eBinding interaction studies (e.g., SPR\/BLI or plate-based binding formats)\u003c\/li\u003e\n\u003cli\u003eCell-based stimulation studies with downstream marker readouts (conceptual)\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eRecombinant constructs may not capture all native isoforms or PTMs.\u003c\/li\u003e\n\u003cli\u003eConsider tag- or host-related effects when interpreting binding or activity.\u003c\/li\u003e\n\u003cli\u003eUse appropriate blanks and matrix\/control concepts to separate signal from background.\u003c\/li\u003e\n\u003c\/ul\u003e\u003c!-- Sources (internal): - UniProtKB P49763 — UniProt — https:\/\/www.uniprot.org\/uniprotkb\/P49763 - NCBI Gene search: PGF — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=PGF - Ensembl search: PGF — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=PGF - Reactome Pathway Browser — Reactome — https:\/\/reactome.org\/ - NCBI Bookshelf — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/books\/ --\u003e","brand":"CUSABIO TECHNOLOGY LLC","offers":[{"title":"500 ug","offer_id":53053375807853,"sku":"CSB-AP002731HU-500UG","price":2618.0,"currency_code":"USD","in_stock":true},{"title":"100 ug","offer_id":53053468737901,"sku":"CSB-AP002731HU-100UG","price":1166.0,"currency_code":"USD","in_stock":true},{"title":"5 ug","offer_id":53053468770669,"sku":"CSB-AP002731HU-5UG","price":142.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/CSB-AP002731HU.jpg?v=1772177533","url":"https:\/\/www.ebiohippo.com\/products\/recombinant-human-placenta-growth-factor-protein-pgf-active-bhp10506028","provider":"BioHippo","version":"1.0","type":"link"}