{"product_id":"recombinant-human-proliferating-cell-antigen-s9-bhp11004595","title":"Recombinant Human Proliferating Cell Antigen, S9","description":"\u003cp\u003e\u003cstrong\u003eRecombinant Human Proliferating Cell Antigen, S9\u003c\/strong\u003e is supplied as a recombinant protein for in vitro research use.\u003c\/p\u003e\n\u003ch3\u003eBackground\u003c\/h3\u003e\n\u003cp\u003eProliferating cell nuclear antigen (PCNA), a protein of 30 kDa molecular weight also known as cyclin, forms a trimer ring around a DNA double-helix. It binds to a variety of other nuclear proteins and thereby organises biochemical processes at the DNA replication fork. PCNA thereby assumes important functions in DNA synthesis, repair and processing, the regulation of cell cycle and even apoptosis. Anti-PCNA antibodies occur in systemic lupus, where they represent a rare specificity (\u0026lt; 10 % of SLE patients). However, their presence alone or in combination with other autoantibodies should alert the clinician to the presence of defined or evolving SLE.\u003c\/p\u003e\n\u003ch3\u003eProduct format\u003c\/h3\u003e\n\u003cp\u003eProvided as a recombinant protein suitable for in vitro workflows such as binding studies, screening, and assay development. Refer to the specifications table for expression format and molecular properties.\u003c\/p\u003e\n\u003ch3\u003eActivity \u0026amp; assay information\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunological functions:\u003c\/strong\u003e 1. Binds IgG-type human auto-antibodies.\u003cbr\u003e2. Standard ELISA test (checker-board analysis of positive\/negative sera panels, immuno-dot analysis with validated SLE patient sera.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCoating concentration:\u003c\/strong\u003e 0.5-1.1 µg\/ml (depending on the type of ELISA plate and coating buffer). Suitable for biotinylation and iodination.\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"ProSpec-Tany TechnoGene Ltd","offers":[{"title":"5 ug","offer_id":53038152188269,"sku":"pro-303-5UG","price":60.0,"currency_code":"USD","in_stock":true},{"title":"20 ug","offer_id":53038482424173,"sku":"pro-303-20UG","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1 mg","offer_id":53038482456941,"sku":"pro-303-1MG","price":4000.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/Prospecbio-pcna-human-sf9-PRO-303.png?v=1782158335","url":"https:\/\/www.ebiohippo.com\/products\/recombinant-human-proliferating-cell-antigen-s9-bhp11004595","provider":"BioHippo","version":"1.0","type":"link"}