{"product_id":"recombinant-human-proprotein-convertase-subtilisin-kexin-type-9-bhp11004265","title":"Recombinant Human Proprotein Convertase Subtilisin\/Kexin Type 9","description":"\u003cp\u003e\u003cstrong\u003eRecombinant Human Proprotein Convertase Subtilisin\/Kexin Type 9\u003c\/strong\u003e is supplied as a recombinant protein for in vitro research use.\u003c\/p\u003e\n\u003ch3\u003eBackground\u003c\/h3\u003e\n\u003cp\u003eProprotein Convertase Subtilisin\/Kexin Type 9 (PCSK9) belongs to the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking via regulated or constitutive branches of the secretory pathway. PCSK9 protein goes through an autocatalytic processing event with its prosegment in the ER and is constitutively secreted as an inactive protease into the extracellular matrix and trans-Golgi network. PCSK9 is expressed in the liver, intestine and kidney tissues and escorts specific receptors for lysosomal degradation. PCSK has a role in cholesterol and fatty acid metabolism. PCSK9 gene mutations are linked with autosomal dominant familial hypercholesterolemia.\u003c\/p\u003e\n\u003ch3\u003eProduct format\u003c\/h3\u003e\n\u003cp\u003eProvided as a recombinant protein suitable for in vitro workflows such as binding studies, screening, and assay development. Refer to the specifications table for expression format and molecular properties.\u003c\/p\u003e","brand":"ProSpec-Tany TechnoGene Ltd","offers":[{"title":"2 ug","offer_id":53038141505901,"sku":"pro-2043-2UG","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10 ug","offer_id":53038462206317,"sku":"pro-2043-10UG","price":145.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/Prospecbio-pcsk9-human-PRO-2043.png?v=1782158316","url":"https:\/\/www.ebiohippo.com\/products\/recombinant-human-proprotein-convertase-subtilisin-kexin-type-9-bhp11004265","provider":"BioHippo","version":"1.0","type":"link"}