{"product_id":"recombinant-human-proteasome-activator-subunit-3-bhp11001675","title":"Recombinant Human Proteasome Activator Subunit 3","description":"\u003cp\u003e\u003cstrong\u003eRecombinant Human Proteasome Activator Subunit 3\u003c\/strong\u003e is supplied as a recombinant protein for in vitro research use.\u003c\/p\u003e\n\u003ch3\u003eBackground\u003c\/h3\u003e\n\u003cp\u003ePSME3 is a member of the PA28 family. The 26S proteasome is an extremely organized multicatalytic proteinase complex composed of 2 complexes, a 20S core and a 19S regulator. Proteasomes are spread all over the eukaryotic cells in large quantities and cleave peptides in an ATP\/ubiquitin-dependent process in a non-lysosomal pathway. PSME3 stimulates the trypsin-like catalytic subunit of the proteasome and inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. PSEM3 enables the MDM2-p53\/TP53 collaboration that encourages ubiquitination- and MDM2-dependent proteasomal degradation of p53\/TP53, restricting its growth and causing inhibited apoptosis after DNA damage.\u003c\/p\u003e\n\u003ch3\u003eProduct format\u003c\/h3\u003e\n\u003cp\u003eProvided as a recombinant protein suitable for in vitro workflows such as binding studies, screening, and assay development. Refer to the specifications table for expression format and molecular properties.\u003c\/p\u003e","brand":"ProSpec-Tany TechnoGene Ltd","offers":[{"title":"2 ug","offer_id":53038068138349,"sku":"pro-987-2UG","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10 ug","offer_id":53038319731053,"sku":"pro-987-10UG","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1 mg","offer_id":53038319763821,"sku":"pro-987-1MG","price":5200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/Prospecbio-psme3-human-PRO-987.png?v=1782158167","url":"https:\/\/www.ebiohippo.com\/products\/recombinant-human-proteasome-activator-subunit-3-bhp11001675","provider":"BioHippo","version":"1.0","type":"link"}