{"product_id":"recombinant-human-protein-phosphatase-1a-alpha-isoform-bhp11001607","title":"Recombinant Human Protein Phosphatase 1A Alpha Isoform","description":"\u003cp\u003e\u003cstrong\u003eRecombinant Human Protein Phosphatase 1A Alpha Isoform\u003c\/strong\u003e is supplied as a recombinant protein for in vitro research use.\u003c\/p\u003e\n\u003ch3\u003eBackground\u003c\/h3\u003e\n\u003cp\u003eProtein Phosphatase 2C alpha is a member of the PP2C family of Ser\/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53\/p53, which leads to G2\/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding two distinct isoforms have been described. Protein phosphatase 2C(PP2C?) is a Mn2+- or Mg2+-dependent protein serine\/threonine phosphatase that is essential for regulating cellular stress response in eukaryotes.\u003c\/p\u003e\n\u003ch3\u003eProduct format\u003c\/h3\u003e\n\u003cp\u003eProvided as a recombinant protein suitable for in vitro workflows such as binding studies, screening, and assay development. Refer to the specifications table for expression format and molecular properties.\u003c\/p\u003e\n\u003ch3\u003eActivity \u0026amp; assay information\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eUnit Definition:\u003c\/strong\u003e One unit will hydrolyze 1 nanomole of p-nitrophenyl phosphatate (pNPP) per minute at pH 7.5 at 37°C.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSpecific Activity:\u003c\/strong\u003e \u0026gt;1,400 U\/mg.\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"ProSpec-Tany TechnoGene Ltd","offers":[{"title":"10 ug","offer_id":53038068793709,"sku":"pka-222-10UG","price":60.0,"currency_code":"USD","in_stock":true},{"title":"50 ug","offer_id":53038318485869,"sku":"pka-222-50UG","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1 mg","offer_id":53038318518637,"sku":"pka-222-1MG","price":1800.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/Prospecbio-ppm1a-human-PKA-222.png?v=1782158167","url":"https:\/\/www.ebiohippo.com\/products\/recombinant-human-protein-phosphatase-1a-alpha-isoform-bhp11001607","provider":"BioHippo","version":"1.0","type":"link"}