{"product_id":"recombinant-human-protein-tyrosine-phosphatase-non-receptor-type-6-bhp11001792","title":"Recombinant Human Protein Tyrosine Phosphatase Non Receptor Type-6","description":"\u003cp\u003e\u003cstrong\u003eRecombinant Human Protein Tyrosine Phosphatase Non Receptor Type-6\u003c\/strong\u003e is supplied as a recombinant protein for in vitro research use.\u003c\/p\u003e\n\u003ch3\u003eBackground\u003c\/h3\u003e\n\u003cp\u003ePTPN6 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene, which encode distinct isoforms, have been reported.\u003c\/p\u003e\n\u003ch3\u003eProduct format\u003c\/h3\u003e\n\u003cp\u003eProvided as a recombinant protein suitable for in vitro workflows such as binding studies, screening, and assay development. Refer to the specifications table for expression format and molecular properties.\u003c\/p\u003e\n\u003ch3\u003eActivity \u0026amp; assay information\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eUnit Definition:\u003c\/strong\u003e One unit will hydrolyze 1 nanomole of p-nitrophenylphosphatate per minute at pH 7.5 at 37°C using 10mM of substrate.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSpecific Activity:\u003c\/strong\u003e \u0026gt;5,000 U\/mg of PTPN6.\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"ProSpec-Tany TechnoGene Ltd","offers":[{"title":"5 ug","offer_id":53038072430957,"sku":"pka-221-5UG","price":60.0,"currency_code":"USD","in_stock":true},{"title":"20 ug","offer_id":53038326153581,"sku":"pka-221-20UG","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1 mg","offer_id":53038326186349,"sku":"pka-221-1MG","price":2800.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/Prospecbio-ptpn6-human-PKA-221.png?v=1782158174","url":"https:\/\/www.ebiohippo.com\/products\/recombinant-human-protein-tyrosine-phosphatase-non-receptor-type-6-bhp11001792","provider":"BioHippo","version":"1.0","type":"link"}