{"product_id":"recombinant-human-protein-unc-13-homolog-a-unc13a-partial-bhp10507684","title":"Recombinant Human Protein unc-13 homolog A (UNC13A), partial","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eThis Recombinant Protein provides recombinant \u003cstrong\u003eUNC13A\u003c\/strong\u003e from Homo sapiens (Human), produced in E.coli (region 1-340aa). It is commonly used as a defined reagent for assay development, binding studies, and mechanistic research (RUO).\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eRegion:\u003c\/strong\u003e 1-340aa (domain boundaries can affect binding\/activity readouts).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eExpression host:\u003c\/strong\u003e E.coli (may differ from native PTMs\/processing).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTag(s):\u003c\/strong\u003e His (supports purification\/detection; consider tag effects in controls).\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cp\u003eAlso reported as Munc13-1 (KIAA1032). Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-dependent refilling of readily releasable vesicle pool. Essential for synaptic vesicle maturation in most excitatory\/glutamatergic but not inhibitory\/GABA-mediated synapses. Also involved in secretory granule priming in insulin secretion. Interacts with FBXO45 ; leading to the degradation of UNC13A by the proteasome. Plays a role in dendrite formation by melanocytes.\u003c\/p\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\u003cli\u003eUse of recombinant standards to improve assay calibration and cross-study comparability.\u003c\/li\u003e\u003c\/ul\u003e\u003cp\u003ePlays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-dependent refilling of readily releasable vesicle pool. Essential for synaptic vesicle maturation in most excitatory\/glutamatergic but not inhibitory\/GABA-mediated synapses. Also involved in secretory granule priming in insulin secretion. Interacts with FBXO45 ; leading to the degradation of UNC13A by the proteasome. Plays a role in dendrite formation by melanocytes.\u003c\/p\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eStandard curve or spike-in reference for quantitative assays involving UNC13A\u003c\/li\u003e\n\u003cli\u003eBinding and specificity benchmarking for detection reagents (conceptual)\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eRecombinant constructs may not capture all native isoforms or PTMs.\u003c\/li\u003e\n\u003cli\u003eConsider tag- or host-related effects when interpreting binding or activity.\u003c\/li\u003e\n\u003cli\u003eUse appropriate blanks and matrix\/control concepts to separate signal from background.\u003c\/li\u003e\n\u003c\/ul\u003e\u003c!-- Sources (internal): - UniProtKB Q9UPW8 — UniProt — https:\/\/www.uniprot.org\/uniprotkb\/Q9UPW8 - NCBI Gene search: UNC13A — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=UNC13A - Ensembl search: UNC13A — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=UNC13A - Reactome Pathway Browser — Reactome — https:\/\/reactome.org\/ - NCBI Bookshelf — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/books\/ --\u003e","brand":"CUSABIO TECHNOLOGY LLC","offers":[{"title":"1 mg","offer_id":53053420634477,"sku":"CSB-EP891983HU-1MG","price":2466.0,"currency_code":"USD","in_stock":true},{"title":"100 ug","offer_id":53053562847597,"sku":"CSB-EP891983HU-100UG","price":578.0,"currency_code":"USD","in_stock":true},{"title":"20 ug","offer_id":53053562880365,"sku":"CSB-EP891983HU-20UG","price":306.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/CSB-EP891983HU-SDS.jpg?v=1772177700","url":"https:\/\/www.ebiohippo.com\/products\/recombinant-human-protein-unc-13-homolog-a-unc13a-partial-bhp10507684","provider":"BioHippo","version":"1.0","type":"link"}