{"product_id":"recombinant-human-pyruvate-dehydrogenase-kinase-isozyme-1-bhp11001751","title":"Recombinant Human Pyruvate Dehydrogenase Kinase Isozyme 1","description":"\u003cp\u003e\u003cstrong\u003eRecombinant Human Pyruvate Dehydrogenase Kinase Isozyme 1\u003c\/strong\u003e is supplied as a recombinant protein for in vitro research use.\u003c\/p\u003e\n\u003ch3\u003eBackground\u003c\/h3\u003e\n\u003cp\u003ePDK1 takes part in the regulation of enzymatic activity of mammalian pyruvate dehydrogenase which is part of a mitochondrial multienzyme complex to catalyze the oxidative decarboxylation of pyruvate and is one of the major enzymes responsible for the regulation of homeostasis of carbohydrate fuels in mammals. PDK1 inhibits glioblastoma growth. PDK1 inhibits the mitochondrial pyruvate dehydrogenase complex by phosphorylation of the e1 alpha subunit, therefore contributing to the regulation of glucose metabolism. PDK1 kinase activity is negatively regulated by binding to 14-3-3.\u003c\/p\u003e\n\u003ch3\u003eProduct format\u003c\/h3\u003e\n\u003cp\u003eProvided as a recombinant protein suitable for in vitro workflows such as binding studies, screening, and assay development. Refer to the specifications table for expression format and molecular properties.\u003c\/p\u003e","brand":"ProSpec-Tany TechnoGene Ltd","offers":[{"title":"10 ug","offer_id":53038069842285,"sku":"pka-263-10UG","price":60.0,"currency_code":"USD","in_stock":true},{"title":"50 ug","offer_id":53038323269997,"sku":"pka-263-50UG","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1 mg","offer_id":53038323302765,"sku":"pka-263-1MG","price":1800.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/Prospecbio-pdk1-human-PKA-263.png?v=1782158170","url":"https:\/\/www.ebiohippo.com\/products\/recombinant-human-pyruvate-dehydrogenase-kinase-isozyme-1-bhp11001751","provider":"BioHippo","version":"1.0","type":"link"}