{"product_id":"recombinant-human-selectin-p-ligand-bhp11006172","title":"Recombinant Human Selectin P Ligand","description":"\u003cp\u003e\u003cstrong\u003eRecombinant Human Selectin P Ligand\u003c\/strong\u003e is supplied as a recombinant protein for in vitro research use.\u003c\/p\u003e\n\u003ch3\u003eBackground\u003c\/h3\u003e\n\u003cp\u003eSELPLG glycoprotein functions as a high affinity counter-receptor for the cell adhesion selectin molecules (P, E and L) located in stimulated T lymphocytes and myeloid cells. SELPLG binds leukocytes to activated platelets or endothelia expressing selectins, a vital role in leukocyte trafficking throughout inflammation. In order to have a high-affinity binding activity SELPLG needs two post-translational modifications, tyrosine sulfation and the addition of the sialyl Lewis x tetrasaccharide (sLex) to its O-linked glycans. Polymorphisms and abnormal expression of SELPLG are linked to defects in the innate and adaptive immune response. Alternate splicing results in multiple transcript variants.\u003c\/p\u003e\n\u003ch3\u003eProduct format\u003c\/h3\u003e\n\u003cp\u003eProvided as a recombinant protein suitable for in vitro workflows such as binding studies, screening, and assay development. Refer to the specifications table for expression format and molecular properties.\u003c\/p\u003e","brand":"ProSpec-Tany TechnoGene Ltd","offers":[{"title":"5 ug","offer_id":53038185021805,"sku":"pro-2714-5UG","price":70.0,"currency_code":"USD","in_stock":true},{"title":"20 ug","offer_id":53038556316013,"sku":"pro-2714-20UG","price":160.0,"currency_code":"USD","in_stock":true},{"title":"1 mg","offer_id":53038556348781,"sku":"pro-2714-1MG","price":5200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/Prospecbio-cd162-human-PRO-2714.png?v=1782158399","url":"https:\/\/www.ebiohippo.com\/products\/recombinant-human-selectin-p-ligand-bhp11006172","provider":"BioHippo","version":"1.0","type":"link"}