{"product_id":"recombinant-human-serta-domain-containing-1-bhp11004851","title":"Recombinant Human SERTA Domain Containing 1","description":"\u003cp\u003e\u003cstrong\u003eRecombinant Human SERTA Domain Containing 1\u003c\/strong\u003e is supplied as a recombinant protein for in vitro research use.\u003c\/p\u003e\n\u003ch3\u003eBackground\u003c\/h3\u003e\n\u003cp\u003eSERTA domain-containing protein (SERTAD1) functions with E2F-responsive promoters to integrate signals provided by PHD- and\/or bromodomain-containing transcription factors. SERTAD1 stimulates E2F-1\/DP-1 transcriptional activity. SERTAD1 reduces the activity of cyclin D1\/CDK4 resistant to the inhibitory effects of p16(INK4a). In addition, SERTAD1 interacts with the PHD-bromodomain of TIF1, TRIM28\/TIF1B and p300\/CBP. Furthermore, SERTAD1 binds to DP1 and interacts with CDK4.\u003c\/p\u003e\n\u003ch3\u003eProduct format\u003c\/h3\u003e\n\u003cp\u003eProvided as a recombinant protein suitable for in vitro workflows such as binding studies, screening, and assay development. Refer to the specifications table for expression format and molecular properties.\u003c\/p\u003e","brand":"ProSpec-Tany TechnoGene Ltd","offers":[{"title":"2 ug","offer_id":53038159135085,"sku":"pro-1157-2UG","price":60.0,"currency_code":"USD","in_stock":true},{"title":"10 ug","offer_id":53038498414957,"sku":"pro-1157-10UG","price":145.0,"currency_code":"USD","in_stock":true},{"title":"100 ug","offer_id":53038498447725,"sku":"pro-1157-100UG","price":1200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/Prospecbio-sertad1-human-PRO-1157.png?v=1782158353","url":"https:\/\/www.ebiohippo.com\/products\/recombinant-human-serta-domain-containing-1-bhp11004851","provider":"BioHippo","version":"1.0","type":"link"}