{"product_id":"recombinant-human-smad-nuclear-interacting-protein-1-bhp11004255","title":"Recombinant Human Smad Nuclear Interacting Protein 1","description":"\u003cp\u003e\u003cstrong\u003eRecombinant Human Smad Nuclear Interacting Protein 1\u003c\/strong\u003e is supplied as a recombinant protein for in vitro research use.\u003c\/p\u003e\n\u003ch3\u003eBackground\u003c\/h3\u003e\n\u003cp\u003eSNIP1 is smad nuclear interacting protein that contains a forkhead-associated (FHA) domain and acts as a nuclear inhibitor of CBP\/p300. SNIP1 is an inhibitor of the TGF-beta signal transduction pathway and is significant in suppressing transcriptional activation dependent on the co-activators CBP and p300. Inhibition of NF-kappa B activity is a function of the N-terminal domain of SNIP1 and involves competition of SNIP1 and the NF-kappa B subunit, RelA\/p65, for binding to p300, similar to the mechanism of inhibition of Smad signaling by SNIP1.\u003c\/p\u003e\n\u003ch3\u003eProduct format\u003c\/h3\u003e\n\u003cp\u003eProvided as a recombinant protein suitable for in vitro workflows such as binding studies, screening, and assay development. Refer to the specifications table for expression format and molecular properties.\u003c\/p\u003e","brand":"ProSpec-Tany TechnoGene Ltd","offers":[{"title":"5 ug","offer_id":53038141047149,"sku":"pro-201-5UG","price":60.0,"currency_code":"USD","in_stock":true},{"title":"20 ug","offer_id":53038461682029,"sku":"pro-201-20UG","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1 mg","offer_id":53038461714797,"sku":"pro-201-1MG","price":2700.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/Prospecbio-snip1-human-PRO-201.png?v=1782158315","url":"https:\/\/www.ebiohippo.com\/products\/recombinant-human-smad-nuclear-interacting-protein-1-bhp11004255","provider":"BioHippo","version":"1.0","type":"link"}